Formulation of Nano Drug Delivery Systems

Gen�, L�tfi; Dikmen, G�khan; G�ney, Gamze
June 2011
Journal of Materials Science & Engineering A;2011, Vol. 1 Issue A, p132
Academic Journal
Nanotechnology by manipulation of characteristics of materials such as polymers and fabrication of nanostructures is able to provide superior drug delivery systems for better management and treatment of diseases. The nanostructures employed as drug delivery systems have multiple advantages which make them superior to conventional delivery systems. Nanoparticles and other colloidal drug delivery systems modify the kinetics, body distribution and drug release of an associated drug. Other effects are tissue or cell specific targeting of drugs and the reduction of unwanted side effects by a controlled release. Micelles in which the most commonly used amphiphilic block copolymer is "Pluronic" a ternary copolymer of poly (ethylene glycol) and poly (propylene oxide). Multifunctional micelles can be prepared throught conjugation of targeting ligands (e.g., folic acid, RGD peptide, antibodies, RNA aptamer and carbohydrates like glucose, lactose, etc.) to their shell aiming to induce specific targeting and uptake by the cells. Liposomes are forms of vehicle that consist either of many, few or just one phospholipid bilayers. Polar drugs can be encapsulated in the liposome core, whereas amphiphilic and lipophilic molecules can be solubilized within the phospholipid bilayer. Dendrimers consist of a central core, branching units and terminal functional groups. Nanoparticles (including nanospheres and nanocapsules) are stable, solid, organic or inorganic particles, with sizes in the range of 10-1000 nm. Nanoparticles tend to be accumulated in tumors, inflammatory and infectious sites by virtue of the enhanced permeability and retention (EPR) effect on the vasculature. Solid lipid nanoparticles (SLN) with lipids which are in solid state at room and body temperature were prepared and stabilized with emulsifer, nanometer size particles. SLN generally solid lipids, emulsifiers and water are formed. Lipid broad term means are used, and triglycerides (tristearin, etc.), partial gliseridleri (Imwitor, etc.), oil acids (stearic acid), steroids (cholesterol) and candles (setil palmitate,etc.) contains. In this study, formulation of implementation and preparation methods of each drug delivery systems used in diagnosis and treatment of various disease have been evaluated. The result of this review, produce and formulation of solid lipid nanoparticles are easier than liposomes, dendrimers and polimeric micelles.


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