TITLE

The Relationship Between Insulin Resistance and Incidence and Progression of Coronary Artery Calcification

AUTHOR(S)
BLAHA, MICHAEL J.; DEFILIPPIS, ANDREW P.; RIVERA, JUAN J.; BUDOFF, MATTHEW J.; BLANKSTEIN, RON; AGATSTON, ARTHUR; SZKLO, MOYSES; LAKOSKI, SUSAN G.; BERTONI, ALAIN G.; KRONMAL, RICHARD A.; BLUMENTHAL, ROGER S.; NASIR, KHURRAM
PUB. DATE
March 2011
SOURCE
Diabetes Care;Mar2011, Vol. 34 Issue 3, p749
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC). RESEARCH DESIGN AND METHODS--We studied 5,464 participants not on hypoglycemic therapy from the Multi-Ethnic Study of Atherosclerosis (MESA). Each had baseline homeostasis model assessment of insulin resistance (HOMA-IR) and baseline and follow-up CAC scores, lncidenl CAC was defined as newly detectable CAC; progression was defined as advancing CAC volume score at follow-up. RESULTS--Median HOMA-IR was 1.2 (0.8-2.0). Across all ethnicities, there was a graded increase in CAC incidence and progression with increasing HOMA-IR. When compared with those in the 1st quartile, participants in the 2nd-4th quartiles had 1.2, 1.5, and 1.8 times greater risk of developing CAC. Median annualized CAC score progression was 8, 14, and 17 higher, respectively. However, HOMA-IR was not predictive after adjustment for metabolic syndrome components. CONCLUSIONS--HOMA-IR predicts CAC incidence and progression, but not independently of metabolic syndrome.
ACCESSION #
61791502

 

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