TITLE

Sıçanlarda izoniazid ve streptomisin nörotoksisitesine sildenafil'in etkileri

AUTHOR(S)
Acar, Abdullah; Fırat, Uğur; Uzar, Ertuğrul; Arıkanoğlu, Adalet; Tüfek, Adnan; Keleş, Ayşenur; Çevik, Mehmet Uğur; Yücel, Yavuz; Alp, Harun; Gökalp, Osman
PUB. DATE
June 2011
SOURCE
Dicle Medical Journal / Dicle Tip Dergisi;2011, Vol. 38 Issue 2, p215
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: Neurotoxicity due to isoniazide (INH) and streptomycin has been reported. Experimental studies reported that sildenafil can reduce toxic effects of some drugs. The aim of this study was to investigate the possible toxic effects of long-term streptomycin and INH use and probable protective effects of sildenafil on the rat brain and cerebellum. Materials and methods: In this study, 78 rats were divided into eight groups as follows; control group (n=10), INH group (n=10), streptomycin group (n=10), INH + streptomycin group (n=10), sildenafil group (n=10), INH+sildenafil group (n=10), streptomycin+sildenafil group (n=8) and INH+streptomycin + sildenafil group (n=10). At the end of 30 days of the treatment, the brain and cerebellar tissues of the rats were examined histopathologically. On the all tissues, inflammation, edema, congestion, degeneration and necrosis were investigated under a light microscope by the same pathologist blinded to the experimental groups. Results: Degeneration was significantly more prominent in the streptomycin group compared with the control group (respectively, p=0.002, p<0.001) on the cerebellum and cerebrum of the rats. INH+streptomycin group showed increased degenerative changes in the brain tissues compared with the INH group (p=0.006). Cerebellar degeneration on the INH+streptomycin+sildenafil group was the most obvious when compared to the control group (p=0.001) and degenerative changes was more obvious in the INH+streptomycin+sildenafil group when compared to the INH+streptomycin group (p=0.032). Conclusion: INH and streptomycin combination showed increased neurotoxicity in the rats. However, sildenafil worsened this neurotoxicity. Electron microscopic and immunohistochemical further studies are needed to investigate some aspects of this toxicity.
ACCESSION #
61443045

 

Related Articles

  • Methods to Identify and Characterize Developmental Neurotoxicity for Human Health Risk Assessment. II: Neuropathology. Garman, Robert H.; Fix, Andrew S.; Jortner, Bernard S.; Jensen, Karl F.; Hardisty, Jerry F.; Claudio, Luz; Ferenc, Susan // Environmental Health Perspectives Supplements;Mar2001 Supplement 1, Vol. 109, p93 

    Part II. Examines the use of developmental neurotoxicity for neuropathologic assessment of laboratory animals following toxicant exposure. Study of rat brains at several developmental stages; Utilization of immunohistochemical procedures for histologic evaluation; Knowledge needed by...

  • Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats. Gurbuz, N; Sagdic, G; Sanli, A; Ciftcioglu, A; Bassorgun, I; Baykal, A; Usta, M F // International Journal of Impotence Research;May/Jun2012, Vol. 24 Issue 3, p114 

    Recently, the relationship between advanced glycation end products (AGEs) and erectile dysfunction (ED) has been reported. The present study aimed to investigate whether a combination of an AGE cross-link breaker (alagebrium/ALT-711) and sildenafil could enhance the erectile capacity in...

  • Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Devan, Bryan D.; Bowker, Jonna L.; Duffy, Kara B.; Bharati, Ila S.; Jimenez, Mariana; Sierra-Mercado Jr., Demetrio; Nelson, Christopher M.; Spangler, Edward L.; Ingram, Donald K. // Psychopharmacology;Jan2006, Vol. 183 Issue 4, p439 

    Rationale: The nitric oxide (NO)--cyclic guanosine monophosphate (cGMP) signal transduction pathway has been implicated in some forms of learning and memory. Recent findings suggest that inhibition of phosphodiesterase (PDE) enzymes that degrade cGMP may have memory-enhancing effects....

  • Evaluation of Large-Sized Brains for Neurotoxic Endpoints. Garman, Robert H. // Toxicologic Pathology;Jan/Feb2003 Supplement 1, Vol. 31, p32 

    Sampling of large-sized brains (eg, dog, primate) for microscopic examination is frequently inadequate to detect localized neurotoxic injury. Furthermore, the examination of H&E-stained sections alone will often be insufficient for the detection of subtle neuropathogic alteration. It is...

  • Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells. Mao, Qing-Qiu; Huang, Zhen; Ip, Siu-Po; Xian, Yan-Fang; Che, Chun-Tao // Cellular & Molecular Neurobiology;May2012, Vol. 32 Issue 4, p531 

    Hyperactivation of the hypothalamic-pituitary-adrenal axis and the associated hippocampal atrophy were observed in patients with depression, which could be ameliorated by the treatment with antidepressants. Therefore, neuroprotection has been proposed to be one of the acting mechanisms of...

  • Anästhetikainduzierte Neurotoxizität. Becke, K.; Schreiber, M.; Philippi-Höhne, C.; Strauß, J.; Engelhard, K.; Sinner, B. // Anaesthesist;Feb2013, Vol. 62 Issue 2, p101 

    No abstract available.

  • Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Duncan, Carlotta E.; An, Mahru C.; Papanikolaou, Theodora; Rugani, Caitlin; Vitelli, Cathy; Ellerby, Lisa M. // Molecular Neurodegeneration;2013, Vol. 8 Issue 1, p1 

    Spinocerebellar ataxia type 7 (SCA7) is caused by a toxic polyglutamine (polyQ) expansion in the N-terminus of the protein ataxin-7. Ataxin-7 has a known function in the histone acetylase complex, Spt/Ada/Gcn5 acetylase (STAGA) chromatin-remodeling complex. We hypothesized that some histone...

  • Studies on sensitivity of zebrafish as a model organism for Parkinson's disease: Comparison with rat model. Makhija, Dinesh T.; Jagtap, Aarti G. // Journal of Pharmacology & Pharmacotherapeutics;Jan-Mar2014, Vol. 5 Issue 1, p39 

    Objective: To determine the utility of zebra fish as an animal model for Parkinson's disease (PD) in comparison with rat model. Materials and Methods: MTT assay was performed on rat and zebrafish brain synaptosomal fractions using rotenone as a neurotoxic agent. Quercetin and resveratrol were...

  • Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice. Plaza-Zabala, Ainhoa; Viñals, Xavier; Maldonado, Rafael; Robledo, Patricia // Psychopharmacology;Mar2010, Vol. 208 Issue 4, p563 

    Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) produces mainly dopaminergic neurotoxicity in mice. However, the consequences of this exposure on the behavioural responses related to natural reinforcing stimuli are still largely unknown. We examined whether repeated treatment...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics