TITLE

Vitreous inflammatory factors in macular edema with central retinal vein occlusion

AUTHOR(S)
Noma, Hidetaka; Funatsu, Hideharu; Harino, Seiyo; Mimura, Tatsuya; Eguchi, Shuichiro; Hori, Sadao
PUB. DATE
May 2011
SOURCE
Japanese Journal of Ophthalmology;May2011, Vol. 55 Issue 3, p248
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) and vascular endothelial growth factor (VEGF) with macular edema in patients with central retinal vein occlusion (CRVO). Methods: Twenty-nine patients who had CRVO with macular edema and 16 patients with non-ischemic ocular diseases (control group) participated. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with fluorescein angiography and the public domain Scion Image program. Macular edema was examined by optical coherence tomography. Vitreous samples were obtained during pars plana vitrectomy. VEGF and sICAM-1 levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay. Results: The median vitreous levels of VEGF and sICAM-1 were significantly higher in the CRVO patients than in the control group [366 vs. 15.6 pg/ml ( P < 0.001) and 20.5 vs. 5.0 ng/ml ( P < 0.001), respectively]. Vitreous levels of both VEGF and sICAM-1 were also significantly higher in the CRVO patients who had retinal ischemia than in those without ischemia ( P < 0.001 and P = 0.011, respectively). Vitreous levels of VEGF and sICAM-1 were also significantly correlated with the severity of macular edema ( P = 0.004 and P = 0.012, respectively). Conclusions: VEGF and sICAM-1 may both increase vascular permeability in CRVO patients with macular edema, with sICAM-1 acting together with and/or via VEGF.
ACCESSION #
61351200

 

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