TITLE

Progress of CypA and Lung Cancer-related Research

AUTHOR(S)
Zhe QIAN; Wentao YUE; Baolan LI
PUB. DATE
August 2010
SOURCE
Chinese Journal of Lung Cancer;Aug2010, Vol. 13 Issue 8, p827
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CypA is the most important member of Cyclophilins. It is a widely expressed protein in nature possessing PPIase and chaperone activities which help the precise folding of protein. Also, it is involved in immunosuppression, inflammation and the balance of cholesterol. As the understanding of CypA function has deepened, people began to realize that there might exist a relationship between CypA and cancer. Lung cancer is the first carcinoma which was found as expressing high level of CypA. CypA plays the roles in increasing proliferation, antiapoptosis, invasion and metastasis in lung cancer. The study of CypA may open a new window for the early diagnosis, prognosis and novel therapeutic drugs targeting.
ACCESSION #
61290011

 

Related Articles

  • Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer. Balgkouranidou, I; Chimonidou, M; Milaki, G; Tsarouxa, E G; Kakolyris, S; Welch, D R; Georgoulias, V; Lianidou, E S // British Journal of Cancer;4/15/2014, Vol. 110 Issue 8, p2054 

    Background:Breast-cancer metastasis suppressor 1 (BRMS1) gene encodes for a predominantly nuclear protein that differentially regulates the expression of multiple genes, leading to suppression of metastasis without blocking orthotropic tumour growth. The aim of the present study was to evaluate...

  • Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer. Li, Haiying; Sun, Liangliang; Xu, Ying; Li, Zixuan; Luo, Wenting; Tang, Zhongping; Qiu, Xueshan; Wang, Enhua // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    The objective of the current study was to investigate the expression pattern and clinicopathological significance of MTA3 in patients with non-small cell lung cancer (NSCLC). The expression profile of MTA3 in NSCLC tissues and adjacent noncancerous lung tissues was detected by...

  • Association between Gene Expression Profiles and Clinical Outcome of Pemetrexed-Based Treatment in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Exploratory Results from a Phase II Study. Fennell, Dean A.; Myrand, Scott P.; Nguyen, Tuan S.; Ferry, David; Kerr, Keith M.; Maxwell, Perry; Moore, Stephen D.; Visseren-Grul, Carla; Das, Mayukh; Nicolson, Marianne C. // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Introduction: We report exploratory gene-expression profiling data from a single-arm Phase-II-study in patients with non-squamous (ns)NSCLC treated with pemetrexed and cisplatin. Previously disclosed results indicated a significant association of low thymidylate-synthase (TS)-expression with...

  • S100B protein as a possible participant in the brain metastasis of NSCLC. Pang, Xiaowen; Min, Jie; Liu, Lili; Liu, Yi; Ma, Ningqiang; Zhang, Helong // Medical Oncology;Dec2012, Vol. 29 Issue 4, p2626 

    Brain metastasis is a frequent occurrence in lung cancer, especially non-small cell lung cancer (NSCLC), the prognosis for NSCLC with brain metastasis is very poor. Our previous study found high S100B expression in the brain-specific metastatic NSCLC line PC14/B, suggested S100B is closely...

  • Thymidylate synthase (TS) gene expression in primary lung cancer patients: a large-scale study in Japanese population. Tanaka, F.; Wada, H.; Fukui, Y.; Fukushima, M. // Annals of Oncology;Aug2011, Vol. 22 Issue 8, p1791 

    Background: Previous small-sized studies showed lower thymidylate synthase (TS) expression in adenocarcinoma of the lung, which may explain higher antitumor activity of TS-inhibiting agents such as pemetrexed.Patients and methods: To quantitatively measure TS gene expression in a large-scale...

  • The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer. Jiping ZHU; Like YU; Ping ZHAN; Yong SONG; Qin WANG // Chinese Journal of Lung Cancer;Aug2010, Vol. 13 Issue 8, p803 

    Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis. We performed a retrospective study on the cyclin D1 expression in non-small cell lung cancer (NSCLC) according to the clinical...

  • Cutaneous metastasis as the first sign of lung cancer. Ðurić, Milivoje; Makević Ðurić, Mirjana; Gajić, Dobrica; Damjanović, Goran // Archive of Oncology;2013, Vol. 21 Issue 1, p20 

    Cutaneous metastases of lung tumors are occurring in 1-12% of cases. High prevalence of lung cancer increases the likelihood of finding these changes in clinical practice. They are usually in the form of a firm, mobile and painless nodule on the head, neck and chest, and their appearance is a...

  • The expression of estrogen receptors β2, 5 identifies and is associated with Prognosis in non-small cell lung cancer. Liu, Zhaoguo; Liao, Yongde; Tang, Hexiao; Chen, Guang // Endocrine (1355008X);Oct2013, Vol. 44 Issue 2, p517 

    Estrogens play a pivotal role in the development and progression of non-small lung cancer (NSCLC). With the discovery of estrogen receptor β (ERβ) isoforms, some controversial roles of ERβ were explained adequately in NSCLC. In this study, our aim is to elucidate expression,...

  • Pulmonary mucinous adenocarcinomas: architectural patterns in correlation with genetic changes, prognosis and survival. Geles, Abidin; Gruber-Moesenbacher, Ulrike; Quehenberger, Franz; Manzl, Claudia; Effah, Mohamed; Grygar, Elisabeth; Juettner-Smolle, Freyja; Popper, Helmut; Al Effah, Mohamed; Popper, Helmut H // Virchows Archiv;Dec2015, Vol. 467 Issue 6, p675 

    Of pulmonary adenocarcinomas, about 25-30 % of cases is of a mucinous type. Mucinous adenocarcinomas are regarded as more aggressive compared to their non-mucinous counterparts. Invasive mucinous adenocarcinoma, colloid, and enteric adenocarcinomas are variants within adenocarcinomas. We...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics