TITLE

Progress of CypA and Lung Cancer-related Research

AUTHOR(S)
Zhe QIAN; Wentao YUE; Baolan LI
PUB. DATE
August 2010
SOURCE
Chinese Journal of Lung Cancer;Aug2010, Vol. 13 Issue 8, p827
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CypA is the most important member of Cyclophilins. It is a widely expressed protein in nature possessing PPIase and chaperone activities which help the precise folding of protein. Also, it is involved in immunosuppression, inflammation and the balance of cholesterol. As the understanding of CypA function has deepened, people began to realize that there might exist a relationship between CypA and cancer. Lung cancer is the first carcinoma which was found as expressing high level of CypA. CypA plays the roles in increasing proliferation, antiapoptosis, invasion and metastasis in lung cancer. The study of CypA may open a new window for the early diagnosis, prognosis and novel therapeutic drugs targeting.
ACCESSION #
61290011

 

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