TITLE

Expression of GSK3B in peripheral blood of patients with Parkinson's disease

AUTHOR(S)
Filatova, E.; Shadrina, M.; Karabanov, A.; Slominsky, P.; Illarioshkin, S.; Ivanova-Smolenskaya, I.; Limborska, S.
PUB. DATE
June 2011
SOURCE
Molecular Biology;Jun2011, Vol. 45 Issue 3, p417
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding the disease pathogenesis and for identifying biomarkers of the preclinical stage of PD. In this study, the expression of the glycogen synthase kinase-3 beta gene ( GSK3B) was investigated in the peripheral blood of several groups of neurological patients using reverse transcription reaction and real-time PCR. Our results suggest that the GSK3B expression level cannot serve as a biomarker for early stages of PD.
ACCESSION #
61265484

 

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