TITLE

Modulation of Thyroid Hormone Concentrations in Serum of Rats Coadministered with Perchlorate and Iodide-Deficient Diet

AUTHOR(S)
Kunisue, Tatsuya; Fisher, Jeffrey; Kannan, Kurunthachalam
PUB. DATE
July 2011
SOURCE
Archives of Environmental Contamination & Toxicology;Jul2011, Vol. 61 Issue 1, p151
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Perchlorate can perturb thyroid hormone (TH) homeostasis by competitive inhibition of iodide uptake by the thyroid gland. Until recently, the effects of perchlorate on TH homeostasis were examined by measuring serum concentrations of THs by immunoassay (IA) methods. IA methods are sensitive, but for TH analysis they are compromised by lack of adequate specificity. In this study, we determined the concentrations of six THs: l-thyroxine (T), 3,3′,5-triiodo- l-thyronine (T), 3,3′,5′-triiodo- l-thyronine (rT), 3,5-diiodo- l-thyronine, 3,3′-diiodo- l-thyronine, and 3-iodo- l-thyronine in the serum of rats administered perchlorate by isotope (C-T)-dilution liquid chromatography-tandem mass spectrometry. The method recoveries for THs spiked into a serum matrix were between 97.0% and 115%, with a coefficient of variation of 2.1% to 9.4%. Rats were placed on an iodide-deficient or iodide-sufficient diet for 2.5 months, and for the last 2 weeks of that period they were provided drinking water either without or with perchlorate (10 mg/kg body weight/day). No significant differences in serum concentrations of T and T were observed between rats given iodide-deficient and iodide-sufficient diets for 2 or 2.5 months. After 24 h of perchlorate exposure, significantly lower concentrations of T and T were found in the serum of rats administered the iodide-deficient diet but not in rats administered the iodide-sufficient diet. However, after 2 weeks of perchlorate exposure, TH levels in rats fed the iodide-sufficient diet were also significantly lower than those in control rats. Our results suggest that perchlorate affects TH homeostasis and that such effects are more pronounced under iodide-deficient nutrition.
ACCESSION #
61212138

 

Related Articles

  • Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T4 and TSH. McLanahan, Eva D.; Andersen, Melvin E.; Campbell Jr., Jerry L.; Fisher, Jeffrey W. // Environmental Health Perspectives;May2009, Vol. 117 Issue 5, p731 

    BACKGROUND: Perchlorate (ClO4‾) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4‾ competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic--pituitary--thyroid (HPT)...

  • Environmental Perchlorate and Thiocyanate Exposures and Infant Serum Thyroid Function. Leung, Angela M.; Braverman, Lewis E.; He, Xuemei; Schuller, Kristin E.; Roussilhes, Alexandra; Jahreis, Katherine A.; Pearce, Elizabeth N. // Thyroid;Sep2012, Vol. 22 Issue 9, p938 

    Background: Breastfed infants rely on maternal iodine for thyroid hormone production required for neurodevelopment. Dietary iodine among women of childbearing age in the United States may be insufficient. Perchlorate (competitive inhibitor of the sodium/iodide symporter [NIS]) exposure is...

  • Euthyroid Sick Syndrome. Sharma, Sumit; Agrawal, Preeti; Kabadi, Udaya; Griffin, James E. // Primary Care Reports;Aug2008, Vol. 14 Issue 8, p81 

    The article explores the changes in thyroid hormone metabolism that are seen in patients with euthyroid sick syndrome and the current controversies in treatment of euthyroid sick syndrome with the administration of thyroid hormone. In about 70% of hospitalized patients with nonthyroidal illness...

  • Monitoring Perchlorate Exposure and Thyroid Hormone Status Among Raccoons Inhabiting a Perchlorate-Contaminated Site. Smith, Philip N.; Utley, Sarah J.; Cox, Stephen B.; Anderson, Todd A.; McMurry, Scott T. // Environmental Monitoring & Assessment;Feb2005, Vol. 102 Issue 1-3, p337 

    Perchlorate is a water soluble anion that is readily accumulated in vegetation. It inhibits uptake of iodide into thyroid gland tissue, thereby reducing production of thyroid hormones. Potential raccoon food items including berries, fish, and vegetation collected at a contaminated site contained...

  • The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development. George Mastorakos; Eftychia Karoutsou; Maria Mizamtsidi; George Creatsas // Endocrine (1355008X);Jun2007, Vol. 31 Issue 3, p219 

    The delivery of the appropriate thyroid hormones quantity to target tissues in euthyroidism is the result of unopposed synthesis, transport, metabolism, and excretion of these hormones. Thyroid hormones homeostasis depends on the maintenance of the circulating ‘free’ thyroid hormone...

  • ACTUALIZACIÓN EN EL FUNCIONAMIENTO DE LA GLÁNDULA TIROIDES EN CANINOS. PRIMERA PARTE: FUNCIONAMIENTO NORMAL. Osorio, José Henry; Salazar, Catalina López // Biosalud;ene-jun2011, Vol. 10 Issue 1, p99 

    Objective. To update concepts related to normal function of the thyroid gland in canines. Materials and methods. Information from the last 50 years including the BBCS-LILACS data bases, Fuente Académica, IB-PsycINFO, IB-SSCI, IB-SciELO, Scopus and Scirus, databases as well as historical...

  • (Healthy) Ageing: Focus on Iodothyronines. de Lange, Pieter; Cioffi, Federica; Silvestri, Elena; Moreno, Maria; Goglia, Fernando; Lanni, Antonia // International Journal of Molecular Sciences;Jul2013, Vol. 14 Issue 7, p13873 

    The activity of the thyroid gland diminishes during ageing, but a certain tissue reserve of T3 and its metabolites is maintained. This reserve is thought to play a regulatory role in energy homeostasis during ageing. This review critically assesses this notion. T3 was thought to act...

  • Thyroid Hormone Homeostasis in Brain: Possible Involvement of Adrenergic Phenomenon in Adult Rat. Kundu, Samita; Biswas, Angshuman; Roy, Sumedha; De, Jhuma; Pramanik, Mitali; Ray, Arun K. // Neuroendocrinology;Feb2009, Vol. 89 Issue 2, p140 

    Background: Imbalance in thyroid hormone concentrations has been linked with profound neurobehavioral alterations in the adult. Peripheral hypothyroidism is associated with a phenomenon of central thyroid hormone homeostasis in adult rat. This central homeostasis mechanism could be maintained by...

  • Evaluation of LED photobiomodulation on wound healing in hypothyroid and euthyroid rats. Paraguassú, Gardênia Matos; Xavier, Flávia Calo Aquino; Rodriguez, Tânia Tavares; Ramalho, Maria José Pedreira; Pinheiro, Antônio Luiz Barbosa; Ramalho, Luciana Maria Pedreira // AIP Conference Proceedings;Sep2012, Vol. 1486 Issue 1, p41 

    Thyroid hormone deficiency has been associated to disruption of the body's metabolism, including healing process. LED phototherapy has been shown to be effective in improving healing in many situations, but their usefulness in the improvement of hypothyroidism wound healing remains unknown. The...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics