Variants in the fat mass and obesity associated (FTO) gene are associated with obesity and C-reactive protein levels in Chinese Han populations

Yanlei Sun; Jiazhong Sun; Xiang Wang; Wei You; Mei Yang
December 2010
Clinical & Investigative Medicine;Dec2010, Vol. 33 Issue 6, pE405
Academic Journal
Purpose: Various genetic variants of the fat mass and obesity associated gene (FTO) have been linked to obesity in populations of Europeans. Low- grade inflammation is a key feature of obesity, characterized by elevated plasma levels of C-reactive protein (CRP). In the present study, we have investigated whether the FTO-risk variant is associated with obesity and CRP in the Chinese population. Methods: 1799 individuals aged 50-70 years (896 men and 903 women), including both obese (560 cases) and control individuals, (1200 cases) were recruited. "the FTO rs9939609 polymorphism was tested using sequences retrieval. Waist circumference, body fat, hs-CRP, blood total cholesterol, triglycerides and LDL-C were also measured. Results: "the FTO rs9939609 polymorphism per-A allele was associated with an increased odds ratio for obesity of 1.42 (95%CI 1.23-1.64). "the genotypic odds ratio for obesity was 1.92 (95%CI 1.43-2.57) for the AA genotype, 1.71 (95%CI 1.35-2.16) for the AT genotype. "the association between FTO rs9939609 polymorphism and CRP levels was r=0.78. Conclusion: Our data support the hypothesis that FTO rs9939609 polymorphism is strongly associated with obesity and CRP levels in the Chinese population as reported in the European population.


Related Articles

  • Gamma glutamyltransferase levels and its association with high sensitive C-reactive protein in patients with acute coronary syndromes. Mehmet Yunus Emiroglu; Özlem Batukan Esen; Bulut, Mustafa; Karapinar, Hekim; Kaya, Zekeriya; Akcakoyun, Mustafa; Kargin, Ramazan; Soe Moe Aung; Alizade, Elnur; Pala, Selcuk; Esen, Ali Metin // North American Journal of Medical Sciences;Jul2010, Vol. 2 Issue 7, p306 

    Background: Elevated Gamma-glutamyltransferase (GGT) level is independently correlated with conditions associatedwith increased atherosclerosis, such as obesity, elevated serum cholesterol, high blood pressure and myocardial infarction. It is also demonstrated that serum...

  • Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women. Álvarez-Blasco, Francisco; Martínez-García, Ma Ángeles; Luque-Ramírez, Manuel; Parraza, Naiara; San Millán, José L.; Escobar-Morreale, Héctor F. // PLoS ONE;2009, Vol. 4 Issue 5, p1 

    Background: Hp2 alleles of the haptoglobin α-chain polymorphism reduce the anti-oxidant properties and increase the proinflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might contribute to the increased oxidative...

  • Effects of Weight Loss and Exercise Training on Insulin Resistance and Cardiometabolie Risk Factors in Older Adults. Dube, John J.; Amati, Francesca A.; Stefanovic-Racic, Maja; Toledo, Frederico G.; Rossi, Andrea; Goodpaster, Bret H. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA279 

    Lifestyle modification, including a combination of weight loss and exercise, is especially effective in reducing the incidence of type 2 diabetes (T2DM) in older, high-risk individuals. However, the effects of exercise and diet-induced weight loss on insulin resistance and other cardiometabolic...

  • Genotypes Associated with CRP Elevations. Kuritzky, Louis // Internal Medicine Alert;12/15/2008 Clinical Briefs, p183 

    The article offers information on the relationship between the elevated C-reactive Protein levels and adverse cardiovascular outcomes associated with genotypes identified.

  • Association between baseline levels of C-reactive protein (CRP) and dinucleotide repeat polymorphism in the intron of the CRP gene. Szalai, A.J.; McCrory, M.A.; Cooper, G.S.; Wu, J.; Kimberly, R.P. // Genes & Immunity;Feb2002, Vol. 3 Issue 1, p14 

    Investigates whether a polymorphic dinucleotide repeat in the intron of the C-reactive protein (CRP) gene contributes to variation in baseline CRP. Serum CRP; Effect of genetic polymorphism on CRP expression; Genetic component of CRP.

  • Association of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils. SUDHESAN, ANJANA; RAJAPPA, MEDHA; CHANDRASHEKAR, LAXMISHA; ANANTHANARAYANAN, PALG HAT HARIHARAN; THAPPA, DEVINDER MOHAN; SATHEESH, SANTHOSH; CHANDRASEKARAN, ADITHAN; DEVARAJU, PANNEER // Journal of Clinical & Diagnostic Research;Oct2016, Vol. 10 Issue 10, p1 

    Introduction: Psoriasis is a multi-factorial heritable T-helper Th-1/Th-17 mediated inflammatory disease, affecting the skin. It is associated with co-morbidities such as Cardiovascular Disease (CVD). C-Reactive Protein (CRP) is a good inflammatory marker. CRP rs1205 polymorphism is associated...

  • Cardioprotective Effect of Periodontal Therapy in Metabolic Syndrome: A Pilot Study in Indian Subjects. Aneesha Acharya; Neeta Bhavsar; Bhavesh Jadav; Hiral Parikh // Metabolic Syndrome & Related Disorders;Aug2010, Vol. 8 Issue 4, p335 

    AbstractBackground:Obesity, metabolic syndrome, and atherosclerosis are linked with an increased acute-phase response. Severe periodontal disease is associated with cardiovascular disease as sequelae of a systemic inflammatory response.Objective:The aim of this study was to assess changes in...

  • Non-Insulin Resistant Obese Subjects Show More Postprandial Low Grade Systemic Inflammation than Control Lean Subjects. Caixas, Assumpta; Giménez-Palop, Olga; Broch, Montserrat; Vilardell, Carme; Megia, Ana; Simon, Imma; Giménez-Pérez, Gabriel; Mauricio, Didac; Vendrell, Joan; González-Clemente, Jose-Miguel; Gonzáez-Clemente, Jose-Miguel // Diabetes;Jun2007 Supplement 1, Vol. 56, pA468 

    Obesity and insulin resistance have been associated with low-grade systemic inflammation (LSGI). The aim of this study was to evaluate whether obese patients with normal insulin resistance showed an additional postprandial low-grade systemic inflammation in relation to lean subjects. Seven obese...

  • Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets. Clifton, P. M.; Keogh, J. B.; Foster, P. R.; Noakes, M. // International Journal of Obesity;Dec2005, Vol. 29 Issue 12, p1445 

    Objective: Cardiovascular disease is strongly associated with obesity and there is evidence that weight loss has positive effects on cardiovascular disease risk. The aims of this study were to compare meal replacements (MR) with a conventional low-fat diet as weight loss strategies...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics