TITLE

HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations

AUTHOR(S)
Bryan, Courtney L.; Scott Beard, K.; Pott, Gregory B.; Rahkola, Jeremy; Gardner, Edward M.; Jano, Edward N.; Shapiro, Leland
PUB. DATE
December 2010
SOURCE
Clinical & Investigative Medicine;Dec2010, Vol. 33 Issue 6, pE384
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Several observations suggest the presence of HIV-suppressive factors in the "fluid phase of blood. Alpha-1-antitrypsin (AAT), the most abundant serine protease inhibitor in the circulation, has potent anti-HIV activity in vitro, and may function as an endogenous HIV suppressor. therefore, we assessed serum AAT concentrations for association with HIV infection. Methods: In this cross-sectional study, serum AAT concentrations were measured in 66 persons with HIV infection and in 45 healthy persons (Controls). In the HIV-infected group, antiretroviral therapy (ART) use was assessed and CD4+ T cell levels and plasma HIV RNA were quantified. Results: Median AAT concentration was significantly lower in the HIV-infected group (1.64 mg/mL) in comparison with Controls (1.94 mg/μL; p=0.001). AAT reduction was most pronounced in the HIV-infected subgroup with CD4+ T cell levels >200 cells/μL in comparison with Controls (p<0.01). Serum AAT concentrations <1.0%mg/mL are clinically significant, and concentrations below this level were identified in 4.5% of the HIV infected group and in no Control subjects. No association between AAT levels and viral load or use of ART was observed in HIV-infected subjects. Conclusion: the association between reduced serum AAT concentration and HIV infection is consistent with a role for AAT as an endogenous HIV suppressor.
ACCESSION #
61180831

 

Related Articles

  • Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice. Subramanian, Sandhya; Shahaf, Galit; Ozeri, Eyal; Miller, Lisa M.; Vandenbark, Arthur A.; Lewis, Eli C.; Offner, Halina // Metabolic Brain Disease;Jun2011, Vol. 26 Issue 2, p107 

    lpha-1-antitrypsin (AAT) is the primary circulating serine protease inhibitor, and is known to exert potent anti-inflammatory effects and to inhibit the progression of several autoimmune diseases. In this study, transgenic mice that over-express surfactant-driven human (h)AAT on the C57BL/6...

  • Alpha-1 antitrypsin, inflammation and quality of life. Serapinas, Danielius // Biologija;2012, Vol. 58 Issue 2, p79 

    Alpha-1 antitrypsin (AAT) is the main circulating serine proteinase inhibitor. A number of studies suggest that AAT can also exhibit biological activity independent of inhibition of serine proteases. The aim of the study was to make experimental investigation of AAT influence on monocytes...

  • Expanding the Clinical Indications for α1-Antitrypsin Therapy. Lewis, Eli C. // Molecular Medicine;Jun2012, Vol. 18 Issue 6, p957 

    α1-Antitrypsin (AAT) is a 52-κDa circulating serine protease inhibitor. Production of AAT by the liver maintains 0.9-1.75 mg/mL circulating levels. During acute-phase responses, circulating AAT levels increase more than fourfold. In individuals with one of several inherited mutations in...

  • α1-Antitrypsin Protects β-Cells From Apoptosis. Zhang, Bin; Lu, Yuanqing; Campbell-Thompson, Martha; Spencer, Terry; Wasserfall, Clive; Atkinson, Mark; Song, Sihong // Diabetes;May2007, Vol. 56 Issue 5, p1316 

    β-Cell apoptosis appears to represent a key event in the pathogenesis of type 1 diabetes. Previous studies have demonstrated that administration of the serine proteinase inhibitor α1-antitrypsin (AAT) prevents type 1 diabetes development in NOD mice and prolongs islet allograft survival in...

  • Biopsy of peripheral lymph nodes: a useful tool to diagnose opportunistic diseases in HIV-infected patients. Ramos, Carina Guedes; Goldani, Luciano Zubaran // Tropical Doctor;Jan2011, Vol. 41 Issue 1, p26 

    Peripheral lymphadenopathy is commonly present in HIV-infected patients and has a wide spectrum of differential diagnoses. We carried out a cross-sectional study of peripheral lymph node biopsies performed from January 2004 to December 2008 in HIV-infected patients who attended a tertiary-care...

  • Prevalence of Dyslipidemia and Metabolic Abnormalities in HIV-Infected Patients. Ramezani, Amitis; Mohraz, Minoo; Yadegarinia, Davood; Banifazl, Mohammad; Gachkar, Latif; Jam, Sara; Aghakhani, Arezoo; Eslamifar, Ali; Yaghmaie, Farhad; Nemati, Kambiz; Velayati, Ali Akbar // Acta Medica Iranica;2009, Vol. 47 Issue 2, p83 

    Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. We investigated the prevalence of and factors associated with dyslipidemia in HIV-infected patients in Iran. In this cross-sectional study, 190...

  • Common types of tuberculosis and co-infection with HIV at Private Health Institutions in Ethiopia: a cross sectional study. Alemie, Getahun Asres; Gebreselassie, Feseha // BMC Public Health;2014, Vol. 14 Issue 1, p1 

    Background Tuberculosis is a global emergency predominantly affecting developing countries. HIV has been the single most important reason for acquisition of tuberculosis for many patients. Conversely, tuberculosis can result in rapid progression of HIV disease. Ethiopia is a country affected...

  • Profile Of HIV Positive Clients In An ICTC Of A Private Medical College, Andhra Pradesh: A Situational Analysis. Kommula, V. M.; Mishra, A. K.; Kusneniwar, G.N.; Chappa, S. N.; Rao, K. V. Raghava // National Journal of Integrated Research in Medicine;2012, Vol. 3 Issue 2, p36 

    Background: HIV/AIDS has turned out into global pandemic. In India under National AIDS Control Program (NACP) -III Integrated Counseling and Testing Centers (ICTC) were established throughout the country for providing prevention services through a holistic approach for all segments of the...

  • Association between Taenia solium infection and HIV/AIDS in northern Tanzania: a matched cross sectional-study. Schmidt, Veronika; Kositz, Christian; Herbinger, Karl-Heinz; Carabin, Hélène; Ngowi, Bernard; Naman, Ezra; Wilkins, Patricia P.; Noh, John; Matuja, William; Winkler, Andrea Sylvia // Infectious Diseases of Poverty;12/1/2016, Vol. 5, p1 

    Background: The frequency of Taenia solium, a zoonotic helminth, is increasing in many countries of sub-Saharan Africa, where the prevalence of the human immunodeficiency virus (HIV) is also high. However, little is known about how these two infections interact. The aim of this study was to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics