Allograft morphology and function in heart transplant recipients surviving more than 15 years by magnetic resonance imaging and dual-source computed tomography

Mastrobuoni, Stefano; Dell’Aquila, Angelo Maria; Arraiza, Maria; Bastarrika, Gorka; Azcarate, Pedro Maria; Pueyo, Jesus; Rabago, Gregorio; Herreros, Jesus
July 2011
European Journal of Cardio-Thoracic Surgery;Jul2011, Vol. 40 Issue 1, pe62
Academic Journal
Abstract: Objective: Cardiac allograft vasculopathy and late graft failure are the main limiting factors of long-term success of heart transplantation, and little is known about graft function in the long-term survivors. The aim of this study was to assess the ventricular function and the allograft vasculopathy in long-term survivors (>15 years) with the cardiac magnetic resonance imaging (MRI) and dual-source computed tomography (DSCT) coronary angiogram. Methods: In our database, 34 cardiac recipients have more than 15 years of follow-up and were evaluated for this study; 22 (65%) of them were enrolled. Mean age at transplant was 46±13.5 years, mean donor age was 28.5±10.1 years, and mean graft ischemic time was 189±58min. Mean follow-up was 18.5±2.4 years (range 15–22). All patients underwent cardiac MRI and DSCT. Results: Mean left ventricular (LV) volumes indexed to the body surface area (BSA) were within normal range: the end-diastolic volume/BSA was 61±16mlm−2, end-systolic volume/BSA was 22±15mlm−2, stroke volume/BSA was 38±6mlm−2, LV mass/BSA: 72±18gm−2, and mean ejection fraction (EF) was 0.59±0.08. Two patients (9%) showed a global cardiac hypokinesia and two other patients (9%) showed akinesia of one segment. At DSCT, 41% of patients had a strictly normal coronary angiogram, 41% had wall thickening and 18% presented a least one >60% stenosis. Conclusions: Cardiac MRI and DSCT coronary angiogram revealed a normal graft function and morphology after more than 15 years of transplantation. However, a certain number of patients have significant cardiac allograft vasculopathy and another consistent group has initial disease. These patients deserve further follow-up and tailoring of the immunosuppressive regimen.


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