TITLE

Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis

AUTHOR(S)
Kaplan, Nicole A.; Colosimo, Pamela F.; Xiaoping Liu; Tolwinski, Nicholas S.
PUB. DATE
April 2011
SOURCE
PLoS ONE;2011, Vol. 6 Issue 4, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton.
ACCESSION #
61167913

 

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