The effect of combined tocolysis on in vitro uterine contractility in preterm labour

Kuć, P.; Laudański, P.; Pierzyński, P.; Laudański, T.
June 2011
Advances in Medical Sciences (De Gruyter Open);2011, Vol. 56 Issue 1, p88
Academic Journal
Purpose: Animal models have confirmed high efficiency of combined tocolytic treatment in preterm labour. In humans, the recommended doses of tocolytic drugs prolong pregnancy in threatened preterm labour. The aim of the study was to evaluate the inhibitory effect of dual combinations of atosiban, nifedipine and celecoxib on human myometrial strips contractility on the in vitro model of preterm labour.Material/Methods: Two groups of patients who delivered by cesarean section were involved in the study: 36 patients who delivered preterm between the 24th and 34th week of pregnancy and 40 patients who delivered at term. Myometrial samples were obtained from the lower uterine segment during cesarean sections. Contractile activity was recorded with digital software for each drug combination: atosiban/nifedipine; atosiban/celecoxib, nifedipine/celecoxib. Tocolytic efficiency of the drug combinations was assessed using IC50 parameter - a molar drug concentration inhibiting 50% of contractility.Results: The atosiban/nifedipine combination has shown additive tocolytic effect on myometrial strips contractility in preterm and term patients. The other combinations: atosiban/celecoxib and nifedipine/celecoxib presented only antagonistic effects in both studied groups.Conclusions: The effect of the combined therapy on human myometrial contractility presented in the study could be a base for further in vivo clinical trials.


Related Articles

  • A New Slow Releasing, H2S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium. Robinson, Hayley; Wray, Susan; Kang Sun // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Better tocolytics are required to help prevent preterm labour. The gaseotransmitter Hydrogen sulphide (H2S) has been shown to reduce myometrial contractility and thus is of potential interest. However previous studies used NaHS, which is toxic and releases H2S as a non-physiological bolus and...

  • Tocolytics: do they actually work? Alfirevic, Zarko // BMJ: British Medical Journal;10/20/2012, Vol. 345 Issue 7879, p7 

    The article discusses tocolytic drugs aimed at preventing preterm birth. Tocolytic drugs such as Calcium-channel blockers and beta-agonists have been used to prevent preterm births but there is absence of the definitive evidence that tocolytics improve child health. It is suggested that in...

  • Nifedipine-Induced Changes in the Electrohysterogram of Preterm Contractions: Feasibility in Clinical Practice. Vinken, Maartje P. G. C.; Rabotti, C.; Mischi, M.; van Laar, J. O. E. H.; Oei, S. G. // Obstetrics & Gynecology International;2010, Vol. 2010, p1 

    Objective. Evaluating changes in the power spectral density (PSD) peak frequency of the electrohysterogram (EHG) caused by nifedipine in women with preterm contractions. Methods. Calculation of the PSD peak frequency in EHG contraction bursts at different times of nifedipine treatment in women...

  • Terbutaline is better than hydration for managing pre-term uterine contractions.  // Modern Medicine;Feb98, Vol. 66 Issue 2, p39 

    Discusses the abstract `Management Options in Women With Preterm Uterine Contractions: A Randomized Clinical Trial,' by D.A. Guinn, A.R. Goepfert, J. Owne et al., which appeared in the October 1997 issue of `American Journal of Obstetrics & Gynecology.'

  • Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. M. Haas, David; M. Caldwell, Deborah; Kirkpatrick, Page; J. Mcintosh, Jennifer; J. Welton, Nicky // BMJ: British Medical Journal;10/20/2012, Vol. 345 Issue 7879, p17 

    The article discusses a systematic review and network meta-analysis to determine the tocolytic with best maternal and neonatal outcomes. It was found that prostaglandin inhibitors and calcium channel blockers had the highest probability of being ranked in the top three medication classes for the...

  • Dos reg�menes de dosis de nifedipino para el manejo del trabajo de parto prematuro: un estudio randomizado controlado (1). Nassar, A. H.; Abu-Musa, A. A.; Awwad, J.; Tabbara, J.; Usta, I. M. // Revista Chilena de Obstetricia y Ginecolog�a;2010, Vol. 75 Issue 5, p343 

    No abstract available.

  • Nifedipine compared to magnesium sulfate for treating preterm labor: A randomized clinical trial. Nikbakht, Roshan; Moghadam, Mahin Taheri; Ghane'ee, Homa // Iranian Journal of Reproductive Medicine;Feb2014, Vol. 12 Issue 2, p145 

    Background: Preterm labor is the leading cause of infant morbidity and mortality so it may be necessary to administer tocolytics for treatment of it. Objective: The aim of this study was to compare the efficacy and safety of magnesium sulfate and nifedipine in the management of preterm labor....

  • A Tocolysis Crisis. KAPLAN, ANDREW I. // Contemporary OB/GYN;Aug2012, Vol. 57 Issue 8, p12 

    The article discusses the legal aspects of the case of a woman who presented to the hospital at 23-week twin gestation with a complaint of vaginal bleeding. The plaintiff alleges that the failure to administer magnesium sulfate as a tocolytic in a timely manner led to the premature delivery of...

  • CURRENT CONCEPTS IN MANAGEMENT OF PRETERM LABOUR-A REVIEW ARTICLE. Singh, Nilanchali; Reddy, Apoorva // Indian Obstetrics & Gynaecology;2015, Vol. 5 Issue 2, p17 

    Prematurity remains a leading cause of neonatal morbidity and mortality in developed countries. It causes 60-80% of infant deaths without congenital anomalies. 1-2 % of all deliveries are below 32 weeks' gestation, whereas, it causes 50% of all long term neurological morbidity & 60% of perinatal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics