Blood pressure in relation to neurogenic, inflammatory and endothelial dysfunction biomarkers in patients with treated essential arterial hypertension

Tycinska, A. M.; Mroczko, B.; Musial, W. J.; Sawicki, R.; Kaminski, K.; Borowska, H.; Sobkowicz, B.; Szmitkowski, M.
June 2011
Advances in Medical Sciences (De Gruyter Open);2011, Vol. 56 Issue 1, p80
Academic Journal
Purpose: Clinical relevance of relations among blood pressure (BP), inflammation, endothelial dysfunction and sympathetic activation is unknown. Study aimed, whether in patients with diagnosed and treated essential arterial hypertension (HTN) biomarkers of inflammation (hs-C-reactive protein, hs-CRP), endothelial dysfunction (endothelin-1, ET-1), and sympathetic nervous system modulation (epinephrine, E and norepinephrine, NE) could be related to BP values.Material and methods: In 62 patients with diagnosed and treated HTN (mean time of disease 5±3.2 years), serum hs-CRP and ET-1 as well as plasma E and NE concentrations were measured. 24-hour ambulatory blood pressure measurement device (ABPM) was used to estimate efficacy of treatment.Results: A positive correlation between epinephrine and norepinephrine concentrations was found (r=0.246, p=0.05), however such a statistically significant correlation neither to hs-CRP, nor ET-1 were found. Patients with the highest hs-CRP and NE concentrations had the highest systolic (SBP) and diastolic (DBP) blood pressure values. Similar relation was found in subgroup of patients with suboptimal blood pressure values (SPB ł 130mmHg, DBP ł 80mmHg). In a group of optimal treated patients, elevated levels of ET-1 and NE related to increased blood pressure values. ROC analysis identified ET-1 as statistically significant to diagnose elevated blood pressure: 0.665 (95% Confidence interval 0.512 to 0.796).Conclusions: In patients with diagnosed and treated arterial hypertension, there are relations among measurements of hs-CRP, ET-1, NE and blood pressure values in spite of treatment, which may improve understanding of mechanisms involving inflammation, endothelial dysfunction and sympathetic nerve activation and may identify patients with refractory hypertension.


Related Articles

  • Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension. Quinaglia, T; Martins, L C; Figueiredo, V N; Santos, R C; Yugar-Toledo, J C; Martin, J F Vilela; Demacq, C; Pimenta, E; Calhoun, D A; Moreno, H // Journal of Human Hypertension;Nov2011, Vol. 25 Issue 11, p656 

    Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and...

  • Conductance and Resistance Vessels in Arterial Hypertension. Levy, B. I.; Kubis, N.; Fressonnet, R.; Safar, M. E. // Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry;Aug2006, Vol. 6 Issue 4, p331 

    More than one-fourth of individuals in the Eastern populations are hypertensive. Both large (conductance) arteries and small (resistance) arterioles are involved in the physiopathology of hypertension. Large arteries from hypertensive subjects are stiffer and thicker than in normotensive matched...

  • CONTEXTUAL ANALYSIS OF THE MEASUREMENT OF BLOOD PRESSURE IN CLINICAL PRACTICE. Pinto Tibúrcio, Manuela; de Vasconcelos Torres, Gilson; Cruz Enders, Bertha; Solange Vieira Tourinho, Francis; de Sousa Martins Melo, Gabriela; Fernandes Costa, Isabelle Katherinne // Revista de Pesquisa: Cuidado e Fundamental;jul-set2013, Vol. 5 Issue 3, p328 

    Objective: to analyze the contextual aspects of blood pressure measurement in clinical practice and understand the factors that determine this phenomenon. Method: Were selected 15 articles in the databases LILACS, MEDLINE and IBECS according with the inclusion criteria: published in Portuguese,...

  • CME Quiz #2.  // Middle East Journal of Family Medicine;Apr2012, Vol. 10 Issue 3, p46 

    A quiz about hypertension and blood pressure measurement is presented.

  • Influence of self-measurement of blood pressure on the responder rate in hypertensive patients treated with losartan: results of the SVATCH Study. Vetter, W; Hess, L; Brignoli, R // Journal of Human Hypertension;Apr2000, Vol. 14 Issue 4, p235 

    Home measurement of blood pressure (BP) can improve compliance. The aim of this study was to evaluate if the efficacy of losartan in hypertension could be enhanced by providing patients with a device for home BP measurement. In this open, randomised, prospective, multi-centre study in 244 Swiss...

  • Systolic Blood Pressure Key for Elderly.  // USA Today Magazine;Oct2000, Vol. 129 Issue 2665, p4 

    Focuses on the importance of measuring blood pressure to prevent the complications of systolic hypertension.

  • Self-blood-pressure monitoring–a questionnaire study: response, requirement, training, support-group popularity and recommendations. Tyson, M J; McElduff, P // Journal of Human Hypertension;Jan2003, Vol. 17 Issue 1, p51 

    The objective of this study was to survey hypertensive patients' response to, requirement for and training in self-blood pressure monitoring (SBPM). A total of 222 hypertensives were invited to complete a questionnaire even when not participating in the project. Questions supplied information on...

  • Sources of error in recording the blood pressure of patients with hypertension in general practice. Patterson, H.R. // British Medical Journal (Clinical Research Edition);12/15/1984, Vol. 289 Issue 6459, p1661 

    Examines the errors in recording blood pressure of patients with hypertension. Preference for terminal digits; Dependence on the protocol accepted by general practitioners; Emergence of inconsistencies between observers.

  • The unsupported arm: a cause of falsely raised blood pressure readings. Silverberg, D.S.; Shemesh, E.; Iaina, A. // British Medical Journal;11/19/1977, Vol. 2 Issue 6098, p1331 

    Evaluates the potentiality of unsupported arm as a cause of falsely raised blood pressure readings. Importance of accurate measurement to evaluate hypertensive patients; Technical errors in the measurement of blood pressure with a sphygmomanometer; Tips for the accurate measurement of blood...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics