Rapid assessment of Hib disease burden in Vietnam

Nyambat, Batmunkh; Duc Anh Dang; Hien Anh Nguyen; Trinh Quynh Mai; Rani, Manju; Slack, Mary P. E.; Kilgore, Paul E.
January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p260
Academic Journal
Background: Several countries have applied the Haemophilus influenzae type b (Hib) rapid assessment tool (RAT) to estimate the burden of Hib disease where resources for hospital- or population-based surveillance are limited. In Vietnam, we used the Hib RAT to estimate the burden of Hib pneumonia and meningitis prior to Hib vaccine introduction. Methods: Laboratory, hospitalization and mortality data were collected for the period January 2004 through December 2005 from five representative hospitals. Based on the WHO Hib RAT protocol, standardized MS Excel spreadsheets were completed to generate meningitis and pneumonia case and death figures. Results: We found 35 to 77 Hib meningitis deaths and 441 to 957 Hib pneumonia deaths among children < 5 years of age annually in Vietnam. Overall, the incidence of Hib meningitis was estimated at 18/100,000 (95% confidence interval, CI, 15.1-21.6). The estimated Hib meningitis incidence in children < 5 years age was higher in Ho Chi Minh City (22.5/100,000 [95% CI, 18.4-27.5]) compared to Hanoi (9.8/100,000 [95% CI, 6.5-14.8]). The Hib RAT suggests that there are a total of 883 to 1,915 cases of Hib meningitis and 4,414 to 9,574 cases of Hib pneumonia per year in Vietnam. Conclusions: In Hanoi, the estimated incidence of Hib meningitis for children < 5 years of age was similar to that described in previous population-based studies of Hib meningitis conducted from 1999 through 2002. Results from the Hib RAT suggest that there is a substantial, yet unmeasured, disease burden associated with Hib pneumonia in Vietnamese children.


Related Articles

  • Systemic Infection with Haemophilus Influenzae type e.  // Clinical Pediatrics;Jun1988, Vol. 27 Issue 6, p288 

    This article presents several case studies on the systemic infection with Hemophilus influenzae type e disease in children. Reports of invasive Hemophilus influenzae type e disease include cases of meningitis, pneumonia, and septic arthritis. It is possible that Hemophilus influenzae type e...

  • Letters. Saeed, Kordo; Stannard, Timothy; Dryden, Matthew; Lambert, Helen // British Journal of General Practice;Oct2011, Vol. 61 Issue 591, p606 

    A letter discusses the treatment to bacterial meningitis which can be due to Streptococcus pneumoniae, Neissaria meningitides and Haemophillus influenzae. The British National Institute for Health and Clinical Excellence (NICE) guidelines suggest the administration of benzylpenicillin for...

  • Long-term follow-up of children with bacterial meningitis with emphasis on behavioural characteristics. Berg, Stefan; Trollfors, Birger; Hugosson, Svante; Fernell, Elisabeth; Svensson, Elisabeth // European Journal of Pediatrics;2002, Vol. 161 Issue 6, p330 

    The sequelae and behaviour in children several years after an episode of bacterial meningitis were studied. All children in Sweden aged 0–4 years with bacterial meningitis between 1987 and 1989 caused by Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis were...

  • Meningitis y neumonía en niños guatemaltecos: importancia de Haemophilus influenzae tipo b y de Streptococcus pnuemoniae. Asturias, Edwin J.; Soto, Monica; Menendez, Ricardo; Ramirez, Patricia L.; Recinos, Fabio; Gordillo, Remei; Holt, Elizabeth; Halsey, Neal A. // Revista Panamericana de Salud Publica;Dec2003, Vol. 14 Issue 6, p377 

    Objective. To determine the epidemiology of Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae invasive infections in hospitalized Guatemalan children. This is an important issue since Hib vaccine has not been incorporated into the routine immunization program in Guatemala and...

  • Multi-center surveillance for pneumonia & meningitis among children (<2 yr) for Hib vaccine probe trial preparation in India. Gupta, Madhu; Kumar, Rajesh; Deb, Alok Kumar; Bhattacharya, Sujit Kumar; Bose, Anuradha; John, Jacob; Balraj, Vinohar; Ganguly, N. K.; Kant, Lalit; Kapoor, Ambujam Nair; Watt, James; Shearer, Jessica; Santosham, Mathuram // Indian Journal of Medical Research;May2010, Vol. 131 Issue 5, p649 

    Background & objectives: Severe clinical pneumonia and meningitis caused by Haemophilus influenzae type b in children less than 5 yr old is preventable by use of Hib vaccine. However, data on Hib burden in India are limited. To support an evidence-based decision for Hib vaccine introduction in...

  • Dynamic Models of Meningococcal Carriage, Disease, and the Impact of Serogroup C Conjugate Vaccination. Trotter, Caroline L.; Gay, Nigel J.; Edmunds, W. John // American Journal of Epidemiology;Jul2005, Vol. 162 Issue 1, p89 

    Much interest has surrounded the use of conjugate vaccines in recent years, with the development of vaccines against disease caused by Haemophilus influenzae type b, Neisseria meningitidis, and Streptococcus pneumoniae. These vaccines offer the potential for safe and effective disease control,...

  • Progress Toward Introduction of Haemophilus influenzae type b Vaccine in Low-Income Countries -- Worldwide, 2004--2007.  // MMWR: Morbidity & Mortality Weekly Report;2/15/2008, Vol. 57 Issue 6, p148 

    The article reports on the introduction of haemophilus influenzae type b (Hib) vaccine to low-income countries from 2004 to 2007. Hib is estimated to cause meningitis and severe pneumonia and death in children below five years old. In 2000, the GAVI Alliance began providing financial support for...

  • Surveillance of Pneumococcal Meningitis among Children in Sindh, Southern Pakistan. Zaidi, Anita K. M.; Khan, Hassan; Lasi, Razzaq; Mahesar, Waheed // Clinical Infectious Diseases;Mar2009 Supplement 2, Vol. 48, pS129 

    Background. Information about the burden of invasive pneumococcal disease among children in Pakistan is limited. Methods. Surveillance of bacterial meningitis among children aged <5 years was set up at 18 hospitals in southern Pakistan that fulfilled the following criteria: (1) >30 pediatric...

  • Estimating Meningitis Hospitalization Rates for Sentinel Hospitals Conducting Invasive Bacterial Vaccine-Preventable Diseases Surveillance. Mathiu, Jason Mwenda; Wijesinghe, Pushpa Ranjan; Agócs, Mary; Burton, Anthony; Sale, James; Van Beneden, Chris; Taylor, Thomas; Flannery, Brendan // MMWR: Morbidity & Mortality Weekly Report;10/4/2013, Vol. 62 Issue 39, p810 

    The article discusses the use of the World Health Organization's (WHO) global invasive bacterial vaccine-preventable diseases (IB-VPD) sentinel hospital surveillance network for estimating meningitis hospitalization rates in the Gambia and Senegal in 2012. The surveillance provides guidance for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics