Simultaneous occurrence of two independent vagal reflexes: a possible cause of vagal sudden death

Alboni, Paolo; Alboni, Marco; Gianfranchi, Lorella
April 2011
Heart;Apr2011, Vol. 97 Issue 8, p623
Academic Journal
A vagal origin of sudden death has been hypothesised in humans, but it has not yet been clearly demonstrated. Two vagal reflexes have been widely investigated: the diving reflex and the fear-induced central reaction, which are responsible for diving bradycardia and alarm bradycardia, respectively. The latter occurs in humans mainly in the context of emotional presyncope/syncope. A simultaneous occurrence of these two vagal reflexes has been observed in animals that are threatened while diving, and heart rates (HR) as low as two to six beats/min have been reported. In experiments carried out in rats, a high percentage of animals that were stressed before immersion in water died suddenly due to progressive slowing of HR; autopsy revealed no signs of drowning. No animals died if they had not been previously stressed. These data show that vagal sudden death can occur when the vagal cardiac fibres are synergically stimulated by two independent reflexes. In humans, it has been reported that in 10-15% of people who die after falling into water, autopsy reveals little or no water in the lungs. These sudden deaths could be due to vagal overactivity. The development of an adequate laboratory model may improve knowledge of the pathophysiology of this type of vagal sudden death and of its prevention.


Related Articles

  • Long-QT Syndrome: A Treated and Saved Case from Sudden Death. Tabiban, Sasan; Ebadi, Seyed Kazem; Golshani, Samad; Amini, Seyed Mohammad // Journal of Mazandaran University of Medical Sciences (JMUMS);Oct/Nov2010, Vol. 20 Issue 78, p76 

    No abstract available.

  • Vasovagal syncope: highlighting an understated event in aesthetic medicine. COLLIER, HELENA // Journal of Aesthetic Nursing;May2014, Vol. 3 Issue 4, p181 

    No abstract available.

  • Vasovagal Syncope Treated as Epilepsy for 16 Years. Asadi-Pooya, Ali Akbar; Nikseresht, Alireza; Yaghoobi, Ehsan // Iranian Journal of Medical Sciences;Mar2011, Vol. 36 Issue 1, p60 

    The differentiation of vasovagal syncope and epileptic seizure is sometimes problematic, since vasovagal syncope may mimic epileptic seizures in many ways. The present report describes a patient who had been diagnosed and treated as having epilepsy with medically-refractory seizures for 16...

  • A number of friends have slid behind the crematorium curtain. Was it something I said? Taylor, Laurie // New Statesman;06/26/2000, Vol. 129 Issue 4492, p63 

    Shares several stories of sudden deaths in Great Britain. Increasing number of people who suffered from sudden deaths; Concern about the issue.

  • Country cardiograms case 44: Answer. Awad, Sara F.M.; Tarakji, Ahmad Raed; Rafie, Ihsan // Canadian Journal of Rural Medicine;Summer2012, Vol. 17 Issue 3, p112 

    The article presents a diagnosis for the case study in the issue regarding a 63-year-old woman suffering from syncope. Heart telemetry of the patient indicated sinus bradycardia and sinus node arrest during sleep. The patient's symptoms, electrocardiography (ECG) results, and blood tests...

  • Blood pressure variability and baroreflex sensitivity of a healthy male during cold pressor test that induced development of neurocardiogenic syncope. Sinha, Biswajit; Dubey, Dinesh K. // Journal of Basic & Clinical Physiology & Pharmacology;Jun2016, Vol. 27 Issue 4, p437 

    Background: The cold pressor test (CPT) is a recognized physiological technique to evaluate autonomic cardiovascular function. The present case study assessed the cardiovascular response of a healthy adult male during 3 min of CPT. Methods: Heart rate (HR) by single-lead electrocardiography and...

  • Recurrent Syncope. Renjel, Robert A.; Steele, Russell W.; Young, Thomas W.; Kashimawo, Lutifat // Clinical Pediatrics;Oct2014, Vol. 53 Issue 12, p1212 

    The article describes the case of an 8 year old Hispanic female presented after 2 syncopal episodes and 2 more episode of syncope while waiting to be examined in the emergency department. A final diagnosis of Vasovagal syncope was made and she was started on PO amoxicillin 500 mg ql2H for...

  • COMBINING THE ACTIVE STAND TEST AND PATTERN RECOGNITION ENABLES VASOVAGAL SYNCOPE PREDICTION. Carmody, M.; Nolan, H.; Fan, C. W.; O'Dwyer, C.; Kenny, R. A.; Finucane, C. // Age & Ageing;Oct2014 Supplement, Vol. 43 Issue suppl_2, pii21 

    Introduction: Vasovagal syncope (VVS) is the most common form of syncope, accounting for 50-60% of unexplained syncope. The gold standard of diagnosis is the Head-Up Tilt (HUT) test, a resource intensive procedure. This study aims to assess the accuracy of applying a pattern recognition...

  • Bradycardic Syncope in 2 Patients Who Recently Began Gatifloxacin Treatment. Nicholson, W.J.; Buxton, A.E.; Tammaro, D. // Clinical Infectious Diseases;2/1/2003, Vol. 36 Issue 3, pe35 

    Gatifloxacin is a synthetic broad-spectrum 8-methoxyfluoroquinolone approved by the United States Food and Drug Administration in December 1999. Few side effects of this new antibiotic have been reported, and there are no previous case reports of bradyarrhythmias. We report 2 cases of syncope...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics