TITLE

Asymptotic confidence interval construction for proportion difference in medical studies with bilateral data

AUTHOR(S)
Nian-Sheng Tang; Shi-Fang Qiu; Man-Lai Tang; Yan-Bo Pei
PUB. DATE
June 2011
SOURCE
Statistical Methods in Medical Research;Jun2011, Vol. 20 Issue 3, p233
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bilateral dichotomous data are very common in modern medical comparative studies (e.g. comparison of two treatments in ophthalmologic, orthopaedic and otolaryngologic studies) in which information involving paired organs (e.g. eyes, ears and hips) is available from each subject. In this article, we study various confidence interval estimators for proportion difference based on Wald-type statistics, Fieller theorem, likelihood ratio statistic, score statistics and bootstrap resampling method under the dependence or/and independence models for bilateral binary data. Performance is evaluated with respect to the coverage probability and expected width via simulation studies. Our empirical results show that (1) ignoring the dependence feature of bilateral data could lead to severely incorrect coverage probabilities; and (2) Wald-type, score-type and bootstrap confidence intervals based on the dependence model perform satisfactorily for small to large sample sizes in the sense that their empirical coverage probabilities are close to the pre-specified nominal confidence level and are hence recommended. A real data from an otolaryngologic study is used to illustrate the proposed methods.
ACCESSION #
60979558

 

Related Articles

  • OPHTHALMOLOGY, OTORHINOLARYNGOLOGY.  // Reference & Research Book News;Feb2012, Vol. 27 Issue 1, p205 

    A bibliography on the subject of ophthalmology and otorhinolaryngology is presented including the books "Photoemulsification," 2th ed. edited by Amar Agarwal and colleagues, "Textbook on Keratoconus: New Insights," by Adel Barbara, and "Cholesteatoma," by Eric E. Smouha and Dennis I. Bojrab.

  • Performance and congestion analysis of the portuguese hospital services. Sim´┐Żes, Pedro; Marques, Rui // Central European Journal of Operations Research;Mar2011, Vol. 19 Issue 1, p39 

    The health care services have been characterized by a growing demand by the citizens leading to the need of more and more resources. Population aging, new pathologies, drugs, as well as new treatments are some of the major factors for this. However, in hospitals, for example, consumption of a...

  • Methods for Mediation Analysis with Missing Data. Zhang, Zhiyong; Wang, Lijuan // Psychometrika;Jan2013, Vol. 78 Issue 1, p154 

    Despite wide applications of both mediation models and missing data techniques, formal discussion of mediation analysis with missing data is still rare. We introduce and compare four approaches to dealing with missing data in mediation analysis including listwise deletion, pairwise deletion,...

  • On the power of bootstrap tests for stationarity: a Monte Carlo comparison. Gulesserian, Sevan; Kejriwal, Mohitosh // Empirical Economics;May2014, Vol. 46 Issue 3, p973 

    This paper studies the behavior of recently proposed bootstrap tests for the null hypothesis of stationarity when the data are generated under the alternative hypothesis of a unit root. Using Monte Carlo experiments and empirical examples, it is shown that the power of these tests critically...

  • Reference region approaches in PET: a comparative study on multiple radioligands. Zanderigo, Francesca; Ogden, R Todd; Parsey, Ramin V // Journal of Cerebral Blood Flow & Metabolism;Jun2013, Vol. 33 Issue 6, p888 

    Reference region (RR) approaches (RRAs) for positron emission tomography (PET) brain studies aim to obtain full quantification without arterial input function (IF) sampling, an invasive and costly procedure. Although they need a reliable RR and are only able to estimate the nondisplaceable...

  • Bootstrapping trust of Web services based on trust patterns and Hidden Markov Models. Yahyaoui, Hamdi; Zhioua, Sami // Knowledge & Information Systems;Nov2013, Vol. 37 Issue 2, p389 

    We propose in this paper a new approach for bootstrapping trust of Web services in which the interactions of a Web service with a user are observed during a certain time frame. The observations sequence is modeled as a Hidden Markov Model and matched against pre-defined trust patterns in order...

  • Is foreign-bank efficiency in financial centers driven by home or host country characteristics? Curi, Claudia; Guarda, Paolo; Lozano-Vivas, Ana; Zelenyuk, Valentin // Journal of Productivity Analysis;Dec2013, Vol. 40 Issue 3, p367 

    This paper investigates whether home or host country factors can explain differences in technical efficiency among foreign banks operating in the Luxembourg financial center. We first address heterogeneity across banks by using the group-wise bootstrap to compare DEA measures of bank efficiency...

  • Comparison of the h-index for different fields of research using bootstrap methodology. Malesios, C.; Psarakis, S. // Quality & Quantity;Jan2014, Vol. 48 Issue 1, p521 

    An important disadvantage of the h-index is that typically it cannot take into account the specific field of research of a researcher. Usually sample point estimates of the average and median h-index values for the various fields are reported that are highly variable and dependent of the...

  • Influence of ion orbit width on onset threshold of neoclassical tearing modes. Huishan Cai; Ding Li; Jintao Cao // Physics of Plasmas;2015, Vol. 22 Issue 10, p1 

    The onset threshold of neoclassical tearing modes with finite ion orbit width is studied. The evolution of neoclassical tearing modes including the effect of ion orbit is derived analytically. When ion orbit width is comparable to island width, the effect of ion orbit is significant. It would...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics