TITLE

Histological and biochemical markers of the liver of Wistar rats on subchronic oral administration of green tea

AUTHOR(S)
Avwioro, Godwin; Iyiola, Sina; Aghoghovwia, Benjamin
PUB. DATE
August 2010
SOURCE
North American Journal of Medical Sciences;Aug2010, Vol. 2 Issue 8, p376
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Few articles have linked the consumption of green tea to certain liver diseases but several articles have disputed these assertions and the consumption of green tea has been on the increase. Aims: The effects of oral administration of green tea on the liver of Wistar rats were studied in order to compare biochemical findings with histological findings. Materials and Methods: 36 male and female Wistar albino rats were grouped into 6, consisting of 6 rats in each group. They were given 1%, 2%, 3%, 4% and 5% concentration of green tea in tap water for 42 days. The 6th group was on normal diet and received 0% of the tea. Their blood samples were analyzed for total and conjugated bilirubin, total protein, albumin, globulin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The liver tissues were also processed for histological examination. Results: The liver tissues were essentially normal and similar to the control tissues. The biochemical parameters studied were also normal and similar to the results obtained from the control animals. Conclusion: Sub chronic consumption of green tea has no injurious effects on the liver of Wistar rats.
ACCESSION #
60948454

 

Related Articles

  • Perfluorocarbon Nanoparticles: Evolution of a Multimodality and Multifunctional Imaging Agent. Winter, Patrick M. // Scientifica;2014, p1 

    Perfluorocarbon nanoparticles offer a biologically inert, highly stable, and nontoxic platform that can be specifically designed to accomplish a range of molecular imaging and drug delivery functions in vivo. The particle surface can be decorated with targeting ligands to direct the agent to a...

  • A Novel Newborn Rat Kernicterus Model Created by Injecting a Bilirubin Solution into the Cisterna Magna. Song, Sijie; Hu, Ying; Gu, Xianfang; Si, Feifei; Hua, Ziyu // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Background: Kernicterus still occurs around the world; however, the mechanism of bilirubin neurotoxicity remains unclear, and effective treatment strategies are lacking. To solve these problems, several kernicterus (or acute bilirubin encephalopathy) animal models have been established, but...

  • Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Kannan, Narayanan; Sakthivel, Kunnathur Murugesan; Guruvayoorappan, Chandrasekaran // Advances in Pharmacological Sciences;2013, p1 

    Thepotential biological functions of A. nilotica have long been described in traditional system of medicine. However, the protective effect of A. nilotica on acetaminophen-induced hepatotoxicity is still unknown. The present study attempted to investigate the protective effect of A. nilotica...

  • Editorial. Mody, Hardik R. // Chronicles of Young Scientists;Oct2011, Vol. 2 Issue 4, p177 

    An introduction is presented in which the editor discusses various reports within the issue on topics including novel drug delivery system, animal models and nanoparticles.

  • Green Tea Protects Testes against Atrazine-induced Toxicity in Rat. Kheirandish, Reza; Azizi, Shahrzad; Abshenas, Jalil; Adabi, Anis // Iranian Journal of Toxicology;May/Jun2017, Vol. 11 Issue 3, p27 

    Background: Atrazine (ATZ) is a common herbicide in agriculture for control of grass and broadleaved weeds. It persists in the environment and causes reproductive problems in both human and animals. The present study was aimed at protective effect of green tea against ATZ toxicity in the...

  • Green Tea Induced Cellular Proliferation and the Expression of Transforming Growth Factor-β1 in the Jejunal Mucosa of Fasting Rats. Mathew, Thazhumpal C.; abdeen, Suad M.; Dashti, Hussain; asfar, Sami // Medical Principles & Practice;Aug2017, Vol. 26 Issue 4, p443 

    Objective: The aim of this study was to understand whether or not the protective effect of green tea after fasting-induced damage in the jejunal mucosa of rat is dependent on cell proliferation and the stimulation of specific growth factors.Materials and Methods: Sixty...

  • Immediate and Late Effects of Stress on Kidneys of Prepubertal and Adult Rats. Marchon, Roger Gaspar; Ribeiro, Carina Teixeira; Costa, Waldemar Silva; Sampaio, Francisco José Barcellos; Pereira-Sampaio, Marco Aurélio; de Souza, Diogo Benchimol // Kidney & Blood Pressure Research;Dec2018, Vol. 43 Issue 6, p1919 

    Background/Aims: Stress had been related to physiological and morphological alterations in different organs, however kidney morphology and function after stress conditions are not well-known. To evaluate the effects of chronic stress on renal morphology in prepubertal and adult rats, and to...

  • Biomarkers in Liver Disease: Emerging Methods and Potential Applications. Aithal, Guruprasad P.; Guha, Neil; Fallowfield, Jonathan; Castera, Laurent; Jackson, Andrew P. // International Journal of Hepatology;2012, p1 

    An introduction is presented in which the editor discusses various reports within the issue on topics including biomarker discovery, biomarkers of liver injury and biomarkers to assess the injury of liver.

  • In vitro and in vivo evaluations of Theophylline Gastroretentive Mucoadhesive tablets prepared by using natural gums. Senthil, V.; Sureshkumar, R.; Lavanya, K.; Rathi, Varun; Venkatesh, D. Nagasamy; Ganesh, G. N. K.; Jawahar, N.; Gowthamarajan, K. // Journal of Pharmacy Research;Aug2010, Vol. 3 Issue 8, p1961 

    The purpose of the current study was to design gastroretentive mucoadhesive theophylline tablets and to optimize with naturals gums and their combinations. Tablets of theophylline were prepared using direct compression method and were evaluated for parameters such as Weight variation, Hardness,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics