TITLE

'Dippers' flu' and its relationship to PON1 polymorphisms

AUTHOR(S)
Cherry, Nicola; Mackness, Michael; Mackness, Bharti; Dippnall, Martin; Povey, Andrew
PUB. DATE
March 2011
SOURCE
Occupational & Environmental Medicine;Mar2011, Vol. 68 Issue 3, p211
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives Sheep-dippers report an acute flu-like condition (dippers' flu: DF) but the cause and relation to chronic disability are unknown. Methods In a case-referent study previously reported, 175 sheep dippers with chronic disability and 234 referents, sheep dippers in good health, completed an interview with information on dipping, type of pesticide used and health for each year 1970-2000 and gave blood for typing of PON1 polymorphisms. Results Reports of DF were much higher (66.3% 116/175) in the chronically unwell than in those without chronic ill-health (18.0% 42/234: OR=8.99 95% CI 5.69-14.21). No significant relation was seen between reported exposures and DF in those with chronic illness, but risk was higher with concentrate handling in those without. An R allele at position 192 on PON1 related to reports of DF both in those with chronic illness (OR=2.04 95% CI 1.08-3.87) and in those who started dipping after 1969 and were not chronically unwell (OR=2.52 95%CI 1.00-6.37). Interaction between handling diazinon concentrate and PON1 (192R) increased the risk of DF. No precipitating factor was identified in a case-crossover analysis. In the group without chronic illness those with 192R developed DF earlier (risk ratio 2.49 95%CI 1.03-6.02). Conclusion 'Dippers' flu' and chronic ill-health attributed to dipping share a common polymorphism (192R). The interaction between handling diazinon concentrate and PON1 genotype supports the conclusion that organophosphates may cause DF. Sheep dippers who are still healthy but experience 'dippers' flu' may be wise to further limit exposures to organophosphates.
ACCESSION #
60944824

 

Related Articles

  • Availability and use of cypermethrin sheep dips.  // Veterinary Record: Journal of the British Veterinary Association;7/22/2006, Vol. 159 Issue 4, p95 

    The article reports on the availability and use of cypermethrin sheep dips in Great Britain. Agricultural merchants and other authorized suppliers can continue to sell cypermethrin-based sheep dip products until their stocks run out. This is despite the suspension of the marketing authorization...

  • Dip safety survey in NW England. Riley, Jonathan // Farmers Weekly;8/26/2005, Vol. 143 Issue 9, p7 

    Reports on the demand for contractors of sheep dips to participate in a health check survey in England organised by Great Britain's Health and Safety Executive. Objective of the survey; Reason for focusing on contractors.

  • Improving sheepdips. Riley, Jonathan // Farmers Weekly;10/21/2005, Vol. 143 Issue 17, p18 

    Reports on the need for farmers in Wales to improve their sheepdips procedure cited by John Harman, chairman of Great Britain's Environment Agency. Threat posed by sheepdip chemicals on aquatic life; Plan of the agency to work with farmers and landowners to ensure that the right advice on the...

  • Cypermethrin ban could force OP dip comeback. Watts, Andrew // Farmers Weekly;2/24/2006, Vol. 144 Issue 8, p7 

    Reports on the possibility of the utilization of organophosphate sheep dips by sheep farmers after the decision of the Veterinary Medicines Directorate forbid the sale of cypermethrin-based products in Great Britain. Reason behind the suspension; Disappointment of Peter Morris, CEO of the...

  • Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases. Yu, X.; Wieczorek, S.; Franke, A.; Yin, H.; Pierer, M.; Sina, C.; Karlsen, T. H.; Boberg, K. M.; Bergquist, A.; Kunz, M.; Witte, T.; Gross, W. L.; Epplen, J. T.; Alarcón-Riquelme, M. E.; Schreiber, S.; Ibrahim, S. M. // Genes & Immunity;Sep2009, Vol. 10 Issue 6, p601 

    We reported earlier that two mitochondrial gene polymorphisms, UCP2 –866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis (MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory...

  • Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.  // Environmental Health: A Global Access Science Source;2011, Vol. 10 Issue 1, p85 

    The article presents a research that analyzes the reasons for the decrease in the at-risk genotypes for genotoxic effects with the increasing age of Flanders in Belgium. It is mentioned that 399 adults were randomly selected for genotyping. It is observed that the prevalence of at-risk genes...

  • Vegetable crop management strategies to increase the quantity of phytochemicals. Schreiner, M. // European Journal of Nutrition;Mar2005, Vol. 44 Issue 2, p85 

    Background Numerous epidemiological studies show an inverse association between vegetable consumption and chronic diseases such as different types of cancer and cardiovascular disease. Phytochemical's in vegetables are known to be responsible for this observed protective effect. Therefore,...

  • The Role of HLA Promoters in Autoimmunity. Müller-Hilke, Brigitte; Mitchison, N. Avrion // Current Pharmaceutical Design;Oct2006, Vol. 12 Issue 29, p3743 

    Population studies reveal HLA class I and class II gene polymorphisms associated with all the common chronic autoimmune diseases, notably spondylarthropathies, rheumatoid arthritis, multiple sclerosis and type I diabetes. We here discuss the exceptionally high levels of nucleotide diversity in...

  • CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS. Özdilli, Kürşat; Pehlivan, Sacide; Öğret, Yeliz Duvarcı; Sever, Tuğçe; Pehlivan, Mustafa; İşsever, Halim; Oğuz, Fatma Savran // Nobel Medicus Journal;Jan-Apr2014, Vol. 10 Issue 1, p74 

    Objective: Cytokines that are released from activated lymphocytes, monocytes, and macrophages modify the intensity of immune inflammatory responses. Differences in cytokine production are due to sequence variants in cytokine genes. Cytokines are involved in all biological processes related to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics