TITLE

Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis?

AUTHOR(S)
Parolari, Alessandro; Tremoli, Elena; Cavallotti, Laura; Trezzi, Matteo; Kassem, Samer; Loardi, Claudia; Veglia, Fabrizio; Ferrari, Giovanni; Pacini, Davide; Alamanni, Francesco
PUB. DATE
April 2011
SOURCE
Heart;Apr2011, Vol. 97 Issue 7, p523
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Context It is not known whether statin treatment improves clinical outcomes and reduces aortic stenosis progression in non-rheumatic calcific aortic stenosis. Objective A meta-analysis of studies was performed comparing statin therapy with placebo or no treatment on outcomes and on aortic stenosis progression echocardiographic parameters. Data sources The authors searched Medline and Pubmed up to January 2010. Data extraction Two independent reviewers independently abstracted information on study design (prospective vs retrospective or randomised vs non-randomised), study and participant characteristics. Fixed and random effects models were used. A-priori subanalyses assessed the effect of statins on low-quality (retrospective or non-randomised) and on high-quality (prospective or randomised) studies separately. Results Meta-analysis identified 10 studies with a total of 3822 participants (2214 non-statin-treated and 1608 statin-treated); five studies were classified as prospective and five as retrospective; concerning randomisation, three trials were randomised whereas seven were not. No significant differences were found in all-cause mortality, cardiovascular mortality or in the need for aortic valve surgery. Lower-quality (retrospective or non-randomised) studies showed that, in statin-treated patients, the annual increase in peak aortic jet velocity and the annual decrease in aortic valve area were lower, but this was not confirmed by the analysis in high-quality (prospective or randomised) studies. Statins did not significantly affect the progression over time of peak and mean aortic gradient. Conclusions Currently available data do not support the use of statins to improve outcomes and to reduce disease progression in non-rheumatic calcific aortic valve stenosis.
ACCESSION #
60944488

 

Related Articles

  • Statins unlikely to protect against VTE.  // Hem/Onc Today;11/10/2012, Vol. 13 Issue 21, p35 

    The article reports on the results of a meta-analysis that included randomized trials that compared statin use with no statin use, or high-dose statin use with standard dose, with a conclusion that statins provided no protective impact against venous thromboembolic events.

  • Effect of pitavastatin in different SLCO1B1 backgrounds on repaglinide pharmacokinetics and pharmacodynamics in healthy Chinese males. Jie Zhu; Min Song; Hong-Yi Tan; Li-Hua Huang; Zhi-Jun Huang; Chang Liu; Zhi-Min Fu; Yuan-Yuan Huang; Zhi-Rong Tan; Xiao-Ping Chen; Hong Yuan; Guo-Ping Yang // Pakistan Journal of Pharmaceutical Sciences;May2013, Vol. 26 Issue 3, p577 

    The effect of pitavastatin and SLCO1B1 genetic background on the pharmacokinetic and pharmacodynamic properties of repaglinide was investigated. In this randomized, placebo-controlled, crossover study, twelve healthy Chinese males were administered with pitavastatin 4 mg/d or the placebo for 5 d...

  • The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial. Novack, Victor; MacFadyen, Jean; Malhotra, Atul; Almog, Yaniv; Glynn, Robert J.; Ridker, Paul M. // CMAJ: Canadian Medical Association Journal;4/17/2012, Vol. 184 Issue 7, pE367 

    Background: Evidence from observational studies have raised the possibility that statin treatment reduces the incidence of certain bacterial infections, particularly pneumonia. We analyzed data from a randomized controlled trial of rosuvastatin to examine this hypothesis. Methods: We analyzed...

  • Do statins cause fatigue?  // Infectious Disease Alert;Aug2012 Pharmacology Watch, p1 

    The article discusses a study from University of California (UC) San Diego on the association between statins and fatigue and exertional intolerance. More than 1000 patients were randomized to simvastatin, pravastatin, or placebo for six months. It was found that statin users were most likely to...

  • Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Douglas C Cowan // Thorax;Oct2010, Vol. 65 Issue 10, p891 

    BACKGROUND: Statins have anti-inflammatory actions which in theory are potentially beneficial in asthma. Small trials have failed to show a significant benefit, but a systematic study to evaluate the steroid-sparing effect of statin treatment has not been carried out. METHODS: A randomised,...

  • Atherosclerosis, Degenerative Aortic Stenosis and Statins. Novo, Giuseppina; Fazio, Giovanni; Visconti, Claudia; Carità, Patrizia; Maira, Ermanno; Fattouch, Khalil; Novo, Salvatore // Current Drug Targets;Jan2011, Vol. 12 Issue 1, p115 

    No abstract available.

  • Efficacy of Short-Term High-Dose Statin in Preventing Contrast-Induced Nephropathy: A Meta-Analysis of Seven Randomized Controlled Trials. Yongchuan Li; Yawei Liu; Lili Fu; Changlin Mei; Bing Dai // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Background: A few studies focused on statin therapy as specific prophylactic measures of contrast-induced nephropathy have been published with conflicting results. In this meta-analysis of randomized controlled trials, we aimed to assess the effectiveness of shor-term high-dose statin treatment...

  • Langerhans Cell Histiocytosis: an orphan disease. Bannon, Michael // QJM: An International Journal of Medicine;Feb2011, Vol. 104 Issue 2, p87 

    No abstract available.

  • Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients†. Kuhn, Elmar W.; Liakopoulos, Oliver J.; Stange, Sebastian; Deppe, Antje-Christin; Slottosch, Ingo; Choi, Yeong-Hoon; Wahlers, Thorsten // European Journal of Cardio-Thoracic Surgery;Jan2014, Vol. 45 Issue 1, p17 

    The objective of this systematic literature review with meta-analysis was to determine the strength of evidence for a preoperative statin on the reduction of adverse postoperative outcomes in patients undergoing cardiac surgery. Randomized controlled (RCT) and observational trials were searched...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics