Alemtuzumab in Kidney-Transplant Recipients

Markmann, James F.; Fishman, Jay A.
May 2011
New England Journal of Medicine;5/19/2011, Vol. 364 Issue 20, p1968
Academic Journal
The article discusses research which compared single-dose alemtuzumab with conventional induction therapies in kidney transplantation. The first analysis compared alemtuzumab with basiliximab in low-risk transplant recipients which revealed superior prevention of biopsy-confirmed acute rejection, but at the expense of persistent leukopenia and a higher rate of serious infection. In contrast, the second analysis comparing the drug with rabbit antithymocyte globulin in high-risk recipients showed a lack of significant differences between the two.


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