TITLE

Effects of spironolactone on cardiac sympathetic nerve activity and left ventricular remodelling after reperfusion therapy in patients with first ST-segment elevation myocardial INFARCTION

AUTHOR(S)
Kasama, Shu; Toyama, Takuji; Sumino, Hiroyuki; Kumakura, Hisao; Takayama, Yoshiaki; Minami, Kazutomo; Ichikawa, Shuichi; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko
PUB. DATE
May 2011
SOURCE
Heart;May2011, Vol. 97 Issue 10, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses a study to evaluate the hypothesis that spironolactone improves the cardiac sympathetic nerve activity (CSNA) in patients with a first ST-segment elevation myocardian infarction (STEMI) undergoing primary coronary angioplasty. Patients admitted to the coronary care unit with a first STEMI and Thrombolysis in Myocardial Infarction (TIMI) grade 0 to 1 flow at initial coronary angiography were studied. It suggests that adding spironolactone can improve CSNA and prevent left ventricular (LV) remodeling in patients with a first STEMI.
ACCESSION #
60718124

 

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