Effects of spironolactone on cardiac sympathetic nerve activity and left ventricular remodelling after reperfusion therapy in patients with first ST-segment elevation myocardial INFARCTION

Kasama, Shu; Toyama, Takuji; Sumino, Hiroyuki; Kumakura, Hisao; Takayama, Yoshiaki; Minami, Kazutomo; Ichikawa, Shuichi; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko
May 2011
Heart;May2011, Vol. 97 Issue 10, p8
Academic Journal
The article discusses a study to evaluate the hypothesis that spironolactone improves the cardiac sympathetic nerve activity (CSNA) in patients with a first ST-segment elevation myocardian infarction (STEMI) undergoing primary coronary angioplasty. Patients admitted to the coronary care unit with a first STEMI and Thrombolysis in Myocardial Infarction (TIMI) grade 0 to 1 flow at initial coronary angiography were studied. It suggests that adding spironolactone can improve CSNA and prevent left ventricular (LV) remodeling in patients with a first STEMI.


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