TITLE

High-Normal HbA1c Is a Strong Predictor of Type 2 Diabetes in the General Population

AUTHOR(S)
BONORA, ENZO; KIECHL, STEFAN; MAYR, AGNES; ZOPPINI, GIACOMO; TARGHER, GIOVANNI; BONADONNA, RICCARDO C.; WILLEIT, JOHANN
PUB. DATE
April 2011
SOURCE
Diabetes Care;Apr2011, Vol. 34 Issue 4, p1038
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--Glycosylated hemoglobin (HbA1c) recently has been recommended for the diagnosis of diabetes by the American Diabetes Association, but its value in the prediction of type 2 diabetes is poorly understood. In this study we evaluated how high-normal HbA1c levels predict type 2 diabetes. RESEARCH DESIGN AND METHODS--We measured HbA1c in 919 Caucasian subjects, aged 40-79 years, and recorded new cases of type 2 diabetes in the following 15 years. Diabetes was diagnosed with HbA1c. RESULTS--Subjects were stratified according to baseline HbA1c (<5.0, 5.00-5.49 [reference], 5.50-5.99, and 6.00-6.49%). Sex- and age-adjusted hazard ratios (95% CI) for type 2 diabetes were 1.11 (0.30-4.41), 1.00, 3.79 (1.79-8.06), and 12.50 (5.51-28.34), respectively. Results did not change after adjusting for several putative confounding factors and were confirmed when models with updated variables were used. CONCLUSIONS-HbA1c is an independent risk factor for type 2 diabetes. Subjects with high-normal levels of HhA1c deserve particular attention because they have a strong risk of developing diabetes.
ACCESSION #
60705098

 

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