Fasting Indicators of Insulin Sensitivity: Effects of Ethnicity and Pubertal Status

April 2011
Diabetes Care;Apr2011, Vol. 34 Issue 4, p994
Academic Journal
OBJECTIVE--To examine the relationship of fasting indicators of insulin sensitivity with a more invasive measure of insulin sensitivity (frequently sampled intravenous glucose tolerance test [FSIVGTT]) and the effect of Tanner stage and ethnicity on that relationship. RESEARCH DESIGN AND METHODS--Data were analyzed from 149 overweight girls (97 Hispanic and 52 African American) who were either in the early stages of maturation defined by Tanner stages 1 or 2 (52 Hispanic and 18 African American) or in the later stages of maturation defined by Tanner stages 4 and 5 (45 Hispanic and 34 African American). Fasting indicators of insulin sensitivity (IS) included fasting insulin and glucose and the homeostasis model assessment of insulin resistance (HOMA-IR). IS was derived from an FSIVGTT with minimal modeling. RESULTS--In Tanner stages 1 and 2, all fasting indicators were significantly associated with IS: (fasting insulin: r = -0.67, P < 0.01; HOMA: r = -0.66, P < 0.01) with no significant influence of ethnicity on these relationships. In Tanner stages 4 and 5, however, all fasting indicators were associated with 1S in African American girls (fasting insulin: r = -0.55, P < 0.01; HOMA: r = -0.47, P < 0.01), but none of the indicators were significantly associated with IS in Hispanic girls. CONCLUSIONS--Fasting indicators were reflective of IS for girls in Tanner stages 1 and 2, regardless of ethnicity and may provide a clinical measure of future risk for type 2 diabetes. In the latter stages of maturation, however, more invasive measures are warranted to adequately determine IS in clinical practice.


Related Articles

  • Whole-Body Insulin Sensitivity Rather than Body-Mass-Index Determines Fasting and Post-Glucose-Load Growth Hormone Concentrations. Anderwald, Christian-Heinz; Tura, Andrea; Gessl, Alois; Smajis, Sabina; Bieglmayer, Christian; Marculescu, Rodrig; Luger, Anton; Pacini, Giovanni; Krebs, Michael // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: Obese, non-acromegalic persons show lower growth hormone (GH) concentrations at fasting and reduced GH nadir during an oral glucose tolerance test (OGTT). However, this finding has never been studied with regard to whole-body insulin-sensitivity as a possible regulator. Methods: In...

  • Different periods of fasting have no effect on oral glucose tolerance. Fielding, J.F.; Toomey, Helen // British Medical Journal;4/8/1978, Vol. 1 Issue 6117, p891 

    It has been suggested that the length of the pretest fast influences the result of an oral glucose tolerance test.[1] In that study the patients who exhibited least carbohydrate tolerance were woken at 0500 for a meal. It seemed possible, therefore, that factors other than the duration of the...

  • Autonomic responses to physiological stressors in women with type 2 diabetes. Franklin, Ruth; Baynard, Tracy; Weinstock, Ruth; Goulopoulou, Styliani; Carhart, Robert; Ploutz-Snyder, Robert; Figueroa, Arturo; Fernhall, Bo; Kanaley, Jill // Clinical Autonomic Research;Apr2008, Vol. 18 Issue 2, p66 

    To compare autonomic function, measured during handgrip (HG) and cold pressor (CP), between obese with and without type 2 diabetes and non-obese women in fasting and post-glucose load states. Twelve obese women with type 2 diabetes (50 � 1 years), 15 obese women without type 2 diabetes (48...

  • Orlistat-aided weight loss helps prevent diabetes in obese persons.  // Geriatrics;Jul2000, Vol. 55 Issue 7, p84 

    Deals with a study which tested the hypothesis that pharmacologically facilitated weight loss improves glucose tolerance and lowers the rate of diabetes onsite in obese persons with regards to Orlistat therapy. Data and methodology; Results; How orlistat can help prevent or delay the onset of...

  • Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/or 60 min during glucose tolerance tests. Jie Hong; Yi-fei Zhang; Wei-qiong Gu; Yu-wen Zhang; Yu-xia Su; Zhen-ni Chi; Wei-qing Wang; Xiao-ying Li; Guang Ning // Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p75 

    Abstract  The purpose of this study was to investigate insulin sensitivity and first-phase insulin secretion in obesity with hyperglycemia in 30 and/or 60 min during oral glucose tolerance (OGTT, glucose ≥ 11.1 mmol/l, post-loading hyperglycemia, PLH) in Chinese...

  • Prevalence of overweight and obesity among adult Malaysians: an update.  // Asia Pacific Journal of Clinical Nutrition;Mar2011, Vol. 20 Issue 1, p35 

    No abstract available.

  • Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Besse-Patin, A; Montastier, E; Vinel, C; Castan-Laurell, I; Louche, K; Dray, C; Daviaud, D; Mir, L; Marques, M-A; Thalamas, C; Valet, P; Langin, D; Moro, C; Viguerie, N // International Journal of Obesity;May2014, Vol. 38 Issue 5, p707 

    Background:It has been suggested that the metabolic benefits of physical exercise could be mediated by myokines. We examined here the effect of exercise training on skeletal muscle expression of a panel of myokines in humans. Pathways regulating myokine expression were investigated in human...

  • Opportunistic random blood glucose best.  // Pulse;4/7/2003, Vol. 63 Issue 14, p18 

    Reports that opportunistic random glucose testing for type 2 diabetes in obese patients is more worthwhile than fasting measurements, according o research in Tayside, Scotland, where diagnosed cases have soared by over 50% in five years.

  • New Insights on the Simultaneous Assessment of Insulin Sensitivity and β-Cell Function With the HOMA2 Method. Caumo, Andrea; Perseghin, Gianluca; Brunani, Amelia; Luzi, Livio // Diabetes Care;Dec2006, Vol. 29 Issue 12, p2733 

    The article presents an overview of a study which evaluated the use of the homeostasis model assessment (HOMA) method in assessing β-cell function and insulin sensitivity. The researchers plotted individual HOMA indexes measured in normoglycemic subjects and median HOMA indexes measured in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics