Incidence of Type 2 Diabetes Using Proposed HbA1c Diagnostic Criteria in the European Prospective Investigation of Cancer-Norfolk Cohort

April 2011
Diabetes Care;Apr2011, Vol. 34 Issue 4, p950
Academic Journal
OBJECTIVE--To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA1c diagnostic criteria in groups categorized by different baseline HbA1c levels. RESEARCH DESIGN AND METHODS--Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat HbA1c measurements, we estimated the prevalence of known and previously undiagnosed diabetes at baseline (baseline HbA1c ≥6.5%) and the incidence of diabetes over 3 years. We also examined the incidence and corresponding odds ratios (ORs) by different levels of baseline HbA1c. Incident diabetes was defined clinically (self-report at follow-up, prescribed diabetes medication, or inclusion on a diabetes register) or biochemically (HbA1c ≥6.5% at the second health assessment), or both. RESULTS--The overall prevalence of diabetes was 4.7%; 41% of prevalent cases were previously undiagnosed. Among 5,735 participants without diabetes at baseline (identified clinically or using HbA1c criteria, or both), 72 developed diabetes over 3 years (1.3% [95% CI 1.0-1.5]), of which 49% were identified using the HbA1c criteria. In 6% of the total population, the baseline HbA1c was 6.0-6.4%: 36% of incident cases arose in this group. The incidence of diabetes in this group was 15 times higher than in those with a baseline HbA1c of <5.0% (OR 15.5 [95% CI 7.2-33.3]). CONCLUSIONS--The cumulative incidence of diabetes defined using a newly proposed HbA1c threshold in this middle-aged British cohort was 1.3% over 3 years. Targeting interventions to individuals with an HbA1c of 6.0-6.4% might represent a feasible preventive strategy, although complementary population-based preventive strategies are also needed to reduce the growing burden of diabetes.


Related Articles

  • Early Insulin Initiation--A Review of the Literature and Case Studies. Coulter, Franklin Carn // Internet Journal of Family Practice;2012, Vol. 10 Issue 1, p1 

    The prevalence of type 2 diabetes (T2D) in the United States has increased in the last decade. Clinical guidelines direct patients with newly diagnosed T2D to a stepwise approach to glycemic management that includes diet, exercise, sequential oral antidiabetic drug (OAD) treatment (from...

  • Epidemiology and Prevention of Type 2 Diabetes Mellitus in children. Nawarathna, Savindika; Jain, Animesh // Journal of International Medicine & Dentistry;2015, Vol. 2 Issue 2, p127 

    Type 2 diabetes mellitus was considered rare amongst children, but recently the incidence has increased worldwide with almost half of the newly diagnosed cases being children and adolescents. Type 2 diabetes mellitus (T2DM) is primarily characterized by insulin resistance detected at the level...

  • Control of type 2 diabetes in King Abdulaziz Housing City (Iskan) population, Saudi Arabia. Alsulaiman, Thamer A.; Al-Ajmi, Hejab A.; Al-Qahtani, Saeed M.; Fadlallah, Intisar M.; Nawar, Nashwa E.; Shukerallah, Reem E.; Nadeem, Sadaf R.; Al-weheedy, Nora M.; Al-sulaiman, Khalid A.; Hassan, Adel A.; Shahin, Ayman A.; Kolib, Tamer M. // Journal of Family & Community Medicine;Jan-Apr2016, Vol. 23 Issue 1, p1 

    Objective: To assess the level of control and prevalence of type 2 diabetes in King Abdulaziz Housing City (Iskan) population of Saudi Arabia. Materials and Methods: Retrospective cross-sectional study conducted in a primary-care setting. All Type 2 diabetics referred to our diabetes center...

  • Glycosylated Hemoglobin: The Importance in Management of Type 2 Diabetes. Yavari, Abbas // Journal of Stress Physiology & Biochemistry;2011, Vol. 7 Issue 4, p122 

    Type 2 diabetes is a major public health problem with high and increasing prevalence, morbidity and mortality. The association between diabetes and microvascular and macrovascular complications is well known besides, tight glycemic control is a necessity. HbA1C has clinically been used since...

  • A NUTTY WAY TO HELP CONTROL TYPE 2 DIABETES.  // Diabetes Health;Oct/Nov2011, Vol. 20 Issue 5, p10 

    The article discusses research at St. Michael's Hospital in Toronto, Ontario, which reveals that eating two ounces of raw, dry, or roasted nuts everyday as a replacement for two ounces of other carbohydrates may control blood sugar levels and cholesterol in type 2 diabetes without gaining...

  • Stress Treatments Helps Control Type 2 Diabetes. Feeney, Donald F. // Nutritional Perspectives: Journal of the Council on Nutrition;Apr2012, Vol. 35 Issue 2, p26 

    The article discusses research which was reported in the January 2002 issue of "Diabetes Care" and found that patients with type two diabetes who incorporate stress management techniques into their routine care can significantly reduce their average blood glucose levels. In the article the...

  • reflections: Bike Maintenance. Joyce, Peter // Diabetes Forecast;May2012, Vol. 65 Issue 5, p76 

    The author discusses the benefits of participating the American Diabetes Association's (ADA) Tour de Cure bicycle ride in the U.S. Being diagnosed with type 2 diabetes, he notes that the six-month training in preparation for the bicycle race has made him lose 25 pounds, lowering his glycated...

  • Ha1c Control Certificate as a Motivating Tool to Control Diabetes. V., Sekar; Babu, Sridhar; J., S. Mala B. Uma Maheswari // Diabetes;Jun2007 Supplement 1, Vol. 56, pA617 

    Aim: The study was planned to find out the HbA1C certificate as a motivating tool for patients to achieve the glycaemic control. Methods and Material: Diabetes being a chronic illness regular follow up is the corner stone in the treatment. To motivate them to come regularly, specially the...

  • Vitamin D Status in Relation to Glucose Metabolism and Type 2 Diabetes in Septuagenarians. DALGÅRD, CHRISTINE; PETERSEN, MARIA SKAALUM; WEIHE, PAL; GRANDJEAN, PHILIPPE // Diabetes Care;Jun2011, Vol. 34 Issue 6, p1284 

    OBJECTIVE--Vitamin D deficiency is thought to be a risk factor for development of type 2 diabetes, and elderly subjects at northern latitudes may therefore be at particular risk. RESEARCH DESIGN AND METHODS--Vitamin D status was assessed from serum concentrations of 25-hydroxyvitamin D3...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics