TITLE

Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly

AUTHOR(S)
AKBARALY, TASNIME N.; ANCELIN, MARIE-LAURE; JAUSSENT, ISABELLE; RITCHIE, CRAIG; BARBERGER-GATEAU, PASCALE; DUFOUIL, CAROLE; KIVIMAKI, MIKA; BERR, CLAUDINE; RITCHIE, KAREN
PUB. DATE
April 2011
SOURCE
Diabetes Care;Apr2011, Vol. 34 Issue 4, p904
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population. RESEARCH DESIGN AND METHODS--This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. RESULTS--After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02-2.95) odds for new-onset depressive symptoms in the youngest age-group (65-70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups. CONCLUSIONS--Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65-70 years.
ACCESSION #
60705076

 

Related Articles

  • The Metabolic Syndrome Is Associated With Circulating Adipokines in Older Adults Across a Wide Range of Adiposity. Tongjian You; Nicklas, Barbara J.; Jingzhong Ding; Penninx, Brenda W. J. H.; Goodpaster, Bret H.; Bauer, Douglas C.; Tylavsky, Frances A.; Harris, Tamara B.; Kritchevsky, Stephen B. // Journals of Gerontology Series A: Biological Sciences & Medical ;Apr2008, Vol. 63 Issue 4, p414 

    Background. Circulating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role...

  • Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in patients with recurrent depressive disorders. Topić, Radmila; Miličić, Davor; Štimac, Zoran; Lončar, Mladen; Velagić, Vedran; Marčinko, Darko; Jakovljević, Miro // Croatian Medical Journal;2013, Vol. 54 Issue 5, p453 

    Aim To investigate the association between depression, metabolic syndrome (MBS), somatic, particularly cardiovascular comorbidity, and low-grade chronic inflammation assessed using C-reactive protein (CRP). Methods This cross-sectional study included 76 patients with recurrent depressive...

  • Psychological Changes following Weight Loss in Overweight and Obese Adults: A Prospective Cohort Study. Jackson, Sarah E.; Steptoe, Andrew; Beeken, Rebecca J.; Kivimaki, Mika; Wardle, Jane // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Background: Participation in weight loss programs is often associated with improved wellbeing alongside reduced cardio-metabolic risk. In contrast, population-based analyses have found no evidence of psychological benefits of weight loss, but this may be due to inclusion of healthy-weight...

  • Effect of Combination Therapy on Cardiovascular Risk in the Pit Miners with Hypertension, Metabolic Syndrome and Depression. Becarevic, Munevera; Barakovic, Fahir; Batic-Mujanovic, Olivera; Beganlic, Azijada // Materia Socio Medica;Apr2014, Vol. 26 Issue 2, p112 

    Background: Higher cardiovascular (CV) morbidity and mortality in depressed patient has demonstrated repeatedly. Aim: Determine the degree of occurrence of hypertension, metabolic syndrome (MetS) and depression in the pit miners and the impact of the six-month holistic treatment of all CV risk...

  • Influence of heart rate at rest for predicting the metabolic syndrome in older Chinese adults. ó Hartaigh, Bríain; Jiang, Chao; Bosch, Jos; Zhang, Wei; Cheng, Kar; Lam, Tai; Thomas, G. // Acta Diabetologica;Jun2013, Vol. 50 Issue 3, p325 

    The aim of this study was to examine the relationship between seated resting heart rate and the metabolic syndrome (MetS) among older residents of Guangzhou, South China. A total of 30,519 older participants (≥50 years) from the Guangzhou Biobank Cohort Study were stratified into quartiles...

  • BMI Versus the Metabolic Syndrome in Relation to Cardiovascular Risk in Elderly Chinese Individuals. Yao He; Bin Jiang; Jie Wang; Kang Feng; Qing Chang; Shanxiang Zhu; Li Fan; Xiaoying Li; Hu, Frank B. // Diabetes Care;Aug2007, Vol. 30 Issue 8, p2128 

    OBJECTIVE -- The purpose of this study was to evaluate the associations of BMI versus metabolic syndrome with cardiovascular diseases (CVDs) in elderly Chinese individuals. RESEACH DESIGN AND METHODS -- We conducted a population-based cross-sectional study in an urban sample of 2,334 elderly...

  • Metabolic Syndrome and All-Cause and Cardiovascular Mortality in an Italian Elderly Population. Zambon, Sabina; Zanoni, Silvia; Sartori, Leonardo; Musacchio, Estella; Romanato, Giovanna; Noale, Marianna; Crepaldi, Gaetano; Manzato, Enzo; Corti, Maria Chiara; Baggio, Giovannella // Diabetes Care;Jan2009, Vol. 32 Issue 1, p153 

    OBJECTIVE -- The purpose of this study was to explore the association of metabolic syndrome and each of its components with all-cause and cardiovascular mortality in a general Italian elderly population. RESEARCH DESIGN AND METHODS -- Metabolic syndrome, diagnosed by National Cholesterol...

  • Association of endothelin-1 and matrix metallopeptidase-9 with metabolic syndrome in middle-aged and older adults. Yu, A. P.; Tam, B. T.; Yau, W. Y.; Chan, K. S.; Yu, S. S.; Chung, T. L.; Siu, P. M. // Diabetology & Metabolic Syndrome;12/10/2015, Vol. 7, p1 

    Background: Metabolic syndrome (MetS) contains a cluster of cardiovascular risk factors. People with MetS are more susceptible to cardiovascular disease, diabetes mellitus, and cancer. Endothelin-1 (ET-1) and matrix metallopeptidase- 9 (MMP-9) have been implicated in the development of...

  • Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population. Yong Wang; Xiaoyan Guo; Heng Ma; Lin Lu; Ruiyan Zhang // Lipids in Health & Disease;1/5/2016, Vol. 15, p1 

    Background: Prokineticin-2 is confirmed to be involved in the inflammatory process. Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS). However, whether prokineticin-2 is associated with MS or not remains unknown. Thus, we present this study to explore the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics