A Physiologic and Pharmacological Basis for Implementation of Incretin Hormones in the Treatment of Type 2 Diabetes Mellitus
- The predictive value of TNF-Î± and IL-6 and the incidence of macrovascular complications in patients with type 2 diabetes. Wu, Weihua; Wang, Mingli; Sun, Zhenjie; Wang, Xin; Miao, Jiajing; Zheng, Zhaohui // Acta Diabetologica;Feb2012, Vol. 49 Issue 1, p3
Some inflammation factors have been shown to accelerate type 2 diabetes macrovascular complication (T2DMC). The study investigates the variation of TNF-Î± and IL-6 levels during the progression of T2DMC to explore their predictive value in the incidence of T2DMC. All participants were divided...
- Oxidative Stress and Heme Oxygenase-1 Regulated Human Mesenchymal Stem Cells Differentiation. Vanella, Luca; Sanford Jr., Christopher; Dong Hyun Kim; Abraham, Nader G.; Ebraheim, Nabil // International Journal of Hypertension;2012, p1
This paper describes the effect of increased expression of HO-1 protein and increased levels of HO activity on differentiation of bone-marrow-derived human MSCs. MSCs are multipotent cells that proliferate and differentiate into many different cell types including adipocytes and osteoblasts. HO,...
- The Irrefutable Importance of Glycemic Control. Ousman, Yasser; Sharma, Meeta // Clinical Diabetes;Spring2001, Vol. 19 Issue 2, p71
Details findings of a prospective observational study designed to determine the relationship between exposure to glycemia over time and the risk of macrovascular and microvascular complications in patients with type 2 diabetes. Primary predefined aggregate clinical outcomes; Incidence of...
- Tight glycemic control may not be best for all patients with diabetes? // Endocrine Today;May2009, Vol. 7 Issue 7, p18
The article discusses research by Victor M. Montori and MercÃ¨ FernÃ¡ndez-Balsells which suggested that tight glycemic control may not reduce the risk for diabetes complications in patients with type 2 diabetes, published in a 2009 issue of "Annals of Internal Medicine."
- Correction. // Diabetes Care;Apr2012, Vol. 35 Issue 4, p939
A correction to the article "Effect of 3-Month Yoga on Oxidative Stress in Type 2 Diabetes With or Without Complications: A Controlled Clinical Trial," that appeared in the 2011 issue of "Diabetes Care" is presented.
- Experts call for early, integrated approach to avoid type 2 diabetes complications. // Endocrine Today;Jun2010 Supplement, Vol. 8, p25
The article highlights the findings of a survey on the views of physicians on the need for increased patient understanding of and early, integrated approach to type 2 diabetes complications.
- Acute Glucose Infusion-Induced Insulin Resistance Occurs Independent of Defects in Insulin Signaling in Skeletal Muscle. Hoy, Andrew J.; Bruce, Clinton R.; Cederberg, Anna; Turner, Nigel; James, David E.; Cooney, Gregory J.; Kraegen, Edward W. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA341
Hyperglycemia is a defining feature of type 1 and 2 diabetes, and contributes directly to the development of the long term complications of diabetes. Hyperglycemia also causes insulin resistance, and we have recently demonstrated that hyperglycemia generated by glucose infusion results, in...
- ZNAÄŒAJ KONTROLE HIPERTENZIJE U TERAPIJI TIPA 2 DIABETES MELLITUSA. Serdarević, Lejla; Semiz, Sabina; Čaušević, Adlija J. // Medical Journal;oct-dec2009, Vol. 15 Issue 4, p196
Diabetes mellitus is a chronic metabolic disease, associated with hyperglycemia and absolute or relative insulin deficiency and insulin resistance. Diabetic patients have a much higher rate of hypertension than non-diabetic individuals, which further leads to accelerated progression of chronic...
- Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure. Miyashita, Yumi; Nishimura, Rimei; Nemoto, Masami; Matsudaira, Toru; Kurata, Hideaki; Yokota, Tamotsu; Yokota, Kuninobu; Tojo, Katsuyoshi; Utsunomiya, Kazunori; Tajima, Naoko // Cardiovascular Diabetology;2008, Vol. 7, p1
Background: The large clinical trials proved that Basal-Bolus (BB) insulin therapy was effective in the prevention of diabetic complications and their progression. However, BB therapy needs multiple insulin injections per a day. In this regard, a biphasic insulin analogue needs only twice-daily...