TITLE

Fractalkine in human inflammatory cardiomyopathy

AUTHOR(S)
Escher, F.; Vetter, R.; Kühl, U.; Westermann, D.; Schultheiss, H-P.; Tschöpe, C.
PUB. DATE
May 2011
SOURCE
Heart;May2011, Vol. 97 Issue 9, p18
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study on the role of fractalkine (CX3CL1) in chemotactic and adhesive properties of peripheral blood mononuclear cells (PBMCs) in patients with inflammatory cardiomyopathy (CMi). It notes the importance of cardiac inflammation for the prognosis of patients with CMi, but the mechanisms leading to the condition are not fully explained. The study finds that the cardiac and plasma CX3CL1/CX3CR1 system is upregulated in CMi, affects the functional potential of PBMCs, and has a cardiodepressive effect in cardiac tissue.
ACCESSION #
60605607

 

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