Translational medicine Heart-brain interactions in cardiac arrhythmia

Taggart, P.; Critchley, H.; Lambiase, P. D.
May 2011
Heart;May2011, Vol. 97 Issue 9, p5
Academic Journal
The article examines current knowledge as of 2011 on the effects of higher brain centres and autonomic control loops on the heart particularly on arrhythmogenesis. Both clinical and experimental observations show direct influences of higher brain activity upon myocardium and cardiac electrophysiology, suggesting psychological stress may evoke arrhythmias. Imaging studies of pro-arrhythmic heart changes implicate mainly the dorsal and subgenual regions of the anterior cingulate cortex, insula cortex and to a lesser extent the amygdala and basal ganglia.


Related Articles

  • Cardiac electrophysiology in mice: a matter of size. Kaese, Sven; Verheule, Sander // Frontiers in Physiology;Aug2012, Vol. 3, preceding p1 

    Over the last decade, mouse models have become a popular instrument for studying cardiac arrhythmias. This review assesses in which respects a mouse heart is a miniature human heart, suitable model for studying mechanisms of cardiac arrhythmias in humans and in which respects human and murine...

  • Heart tissue stimulation could lead to light-guided pacemakers. FORD, OMAR // Medical Device Daily;8/15/2011, Vol. 15 Issue 152, p1 

    The article offers information on a study which described how a new approach to promote heart tissue by low-energy pulses of blue light could result to light-powered pacemakers in the future. It references a study by Emilia Entcheva et al, published in a 2011 issue of the journal "Circulation:...


    Studies the cellular electrophysiologic basis of cardiac arrhythmias. Initiation of the cardiac action potential; Ability of cardiac myocardial and specialized conducting fibers to initiate an action potential in response to an appropriate stimulus; Propagation of the cardiac action potential.

  • Dispersion of cardiac action potential duration and the initiation of re-entry: A computational study. Clayton, Richard H; Holden, Arun V // BioMedical Engineering OnLine;2005, Vol. 4, p11 

    Background: The initiation of re-entrant cardiac arrhythmias is associated with increased dispersion of repolarisation, but the details are difficult to investigate either experimentally or clinically. We used a computational model of cardiac tissue to study systematically the association...

  • En torno a los primeros estudios de electrofisiología. de Micheli, Alfredo // Archivos de Cardiología de México;oct-dic2011, Vol. 81 Issue 4, p337 

    A historical outline of the evolution of electrophysiology from the eighteenth century is shortly presented. Topics concerning the so called animal electricity starting from the observations on descharges of Torpedo fish until Bolognese Galvani's researches on the frogs are exposed. The points...

  • Complications in Patients Undergoing Cardiac Electrophysiologic Procedures. Dimarco, John P.; Garan, Hasan; Ruskin, Jeremy N. // Annals of Internal Medicine;Oct82, Vol. 97 Issue 4, p490 

    Focuses on a study which reported complications associated with 1062 intracardiac electrophysiologic procedures done in patients between September 1977 and August 1981 in Boston, Massachusetts. Methods; Complications of arrhythmias; Discussion of results.

  • Sudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease. Martin, Claire A.; Matthews, Gareth D. K.; Huang, Christopher L-H // Heart;Apr2012, Vol. 98 Issue 7, p536 

    Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and...

  • Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells. Zhao, Zhenghang; Xie, Yuanfang; Wen, Hairuo; Xiao, Dandan; Allen, Charelle; Fefelova, Nadezhda; Dun, Wen; Boyden, Penelope A.; Qu, Zhilin; Xie, Lai-Hua // Cardiovascular Research;8/1/2012, Vol. 95 Issue 3, p308 

    Aims The transient outward potassium current (Ito) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study the effects and mechanisms of Ito on EAD genesis in cardiac...

  • Resetting and annihilation of reentrant activity in a model of a one-dimensional loop of ventricular tissue. Comtois, Philippe; Vinet, Alain // Chaos;Sep2002, Vol. 12 Issue 3, p903 

    Resetting and annihilation of reentrant activity by a single stimulus pulse (S1) or a pair (S1-S2) of coupled pulses are studied in a model of one-dimensional loop of cardiac tissue using a BeelerReuter-type ionic model. Different modes of reentry termination are described. The classical mode of...


Read the Article


Sign out of this library

Other Topics