TITLE

Maternal signals for progeny prevention against allergy and asthma

AUTHOR(S)
Marsh, Leigh; Pfefferle, Petra; Pinkenburg, Olaf; Renz, Harald
PUB. DATE
June 2011
SOURCE
Cellular & Molecular Life Sciences;Jun2011, Vol. 68 Issue 11, p1851
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
llergy and asthma are chronic inflammatory diseases which result from complex gene-environment interactions. Recent evidence indicates the importance of prenatal and postnatal developmental processes in terms of maturation of balanced immune responses. According to the current view, gene-environment interactions during a restricted time frame are responsible for programming of the immune system in favor of allergic immune mechanisms later in life. The interaction between genes and environment is complex and only partially understood; however, heritable epigenetic modifications including chemical additions in and alternative packaging of the DNA have been shown to play a crucial role in this context. Novel data indicate that epigenetic mechanisms contribute to the development of T-helper cell function. Environmental factors, including diesel exhaust particles (DEP), vitamins and tobacco smoke, operate through such mechanisms. Furthermore, the role of environmental microbes provides another and maybe even more important group of exogenous exposures which operates in this critical time frame.
ACCESSION #
60502857

 

Related Articles

  • Gene-environment interactions in chronic inflammatory disease. Renz, Harald; von Mutius, Erika; Brandtzaeg, Per; Cookson, William O; Autenrieth, Ingo B; Haller, Dirk // Nature Immunology;Apr2011, Vol. 12 Issue 4, p273 

    No abstract available.

  • Fleshing Out Filaggrin Phenotypes. Irvine, Alan D. // Journal of Investigative Dermatology;Mar2007, Vol. 127 Issue 3, p504 

    The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated...

  • Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease. Mastroeni, Diego; McKee, Ann; Grover, Andrew; Rogers, Joseph; Coleman, Paul D. // PLoS ONE;2009, Vol. 4 Issue 8, p1 

    DNA methylation [1,2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's...

  • Czy Åšrodowisko może mieć wpÅ‚yw na jakoŚć życia pacjentów z astmÄ… oskrzelowÄ…? Ścibor, Monika; Balcerzak, Bartosz; Malinowska-CieŚlik, Marta // Public Health Management / Zdrowie Publiczne i ZarzÄ…dzanie;2012, Vol. 10 Issue 1, p25 

    Health related quality of life assessment is an topic in public health, especially in socially meaningful chronic diseases. Chronic diseases such as asthma reduce the patient's quality of life significant. The influence of environmental factors on health has been interested researchers for many...

  • Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families. Bouzigon, Emmanuelle; Ulgen, Ayse; Dizier, Marie-Hélène; Siroux, Valérie; Lathrop, Mark; Kauffmann, Francine; Pin, Isabelle; Demenais, Florence // Human Genetics;Jul2007, Vol. 121 Issue 6, p711 

    Although many genome screens have been conducted for asthma as a binary trait, there is limited information regarding the genetic factors underlying variation of asthma expression. Phenotypes related to variable disease expression include time to asthma onset and variation in clinical expression...

  • Association of β2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin-Intolerant Acute Urticaria. Hyoun-Ah Kim; Young-Min Ye; Seung-Hyun Kim; Gyu-Young Hur; Hae-Sim Park // Yonsei Medical Journal;12/31/2008, Vol. 48 Issue 6, p1079 

    The genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the β2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria...

  • Computational Micromodel for Epigenetic Mechanisms. Raghavan, Karthika; Ruskin, Heather J.; Perrin, Dimitri; Goasmat, Francois; Burns, John // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Characterization of the epigenetic profile of humans since the initial breakthrough on the human genome project has strongly established the key role of histone modifications and DNA methylation. These dynamic elements interact to determine the normal level of expression or methylation status of...

  • Determinants of allergic signs and symptoms in 24-48-month- old Turkish children. Özmert, Elif N.; Kale-Çekinmez, Eren; Yurdak^;k, Kadriye; Şekerel, Bülent Enis // Turkish Journal of Pediatrics;Mar/Apr2009, Vol. 51 Issue 2, p103 

    The expression of asthma and allergic diseases depends upon an interaction of genetic and environmental factors and thus may differ between populations. This study was performed to document the factors determining allergic signs and symptoms in early childhood in a group of Turkish children....

  • Reliable Noninvasive Genotyping: Fantasy or Reality? Fernando, P.; Vidya, T.N.C.; Rajapakse, C.; Dangolla, A.; Melnick, D.J. // Journal of Heredity;Mar/Apr2003, Vol. 94 Issue 2, p115 

    Demonstrates the reliability of genotyping from elephant dung using collection, extraction and amplification protocols by comparing results from dung-extracted DNA to results from blood-extracted DNA. Reason that noninvasive genotyping has not gained wide application; Causes of error in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics