TITLE

An evaluation of oxygen systems for treatment of childhood pneumonia

AUTHOR(S)
Catto, Alastair G.; Zgaga, Lina; Theodoratou, Evropi; Huda, Tanvir; Nair, Harish; Arifeen, Shams El; Rudan, Igor; Duke, Trevor; Campbell, Harry
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011 Supplement 3, Vol. 11 Issue Suppl 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Oxygen therapy is recommended for all of the 1.5 - 2.7 million young children who consult health services with hypoxemic pneumonia each year, and the many more with other serious conditions. However, oxygen supplies are intermittent throughout the developing world. Although oxygen is well established as a treatment for hypoxemic pneumonia, quantitative evidence for its effect is lacking. This review aims to assess the utility of oxygen systems as a method for reducing childhood mortality from pneumonia. Methods: Aiming to improve priority setting methods, The Child Health and Nutrition Research Initiative (CHNRI) has developed a common framework to score competing interventions into child health. That framework involves the assessment of 12 different criteria upon which interventions can be compared. This report follows the proposed framework, using a semi-systematic literature review and the results of a structured exercise gathering opinion from experts (leading basic scientists, international public health researchers, international policy makers and representatives of pharmaceutical companies), to assess and score each criterion as their "collective optimism" towards each, on a scale from 0 to 100%. Results: A rough estimate from an analysis of the literature suggests that global strengthening of oxygen systems could save lives of up to 122,000 children from pneumonia annually. Following 12 CHNRI criteria, the experts expressed very high levels of optimism (over 80%) for answerability, low development cost and low product cost; high levels of optimism (60-80%) for low implementation cost, likelihood of efficacy, deliverability, acceptance to end users and health workers; and moderate levels of optimism (40-60%) for impact on equity, affordability and sustainability. The median estimate of potential effectiveness of oxygen systems to reduce the overall childhood pneumonia mortality was ~20% (interquartile range: 10-35%, min. 0%, max. 50%). However, problems with oxygen systems in terms of affordability, sustainability and impact on equity are noted in both expert opinion scores and on review. Conclusion: Oxygen systems are likely to be an effective intervention in combating childhood mortality from pneumonia. However, a number of gaps in the evidence base exist that should be addressed to complete the investment case and research addressing these issues merit greater funding attention.
ACCESSION #
60440508

 

Related Articles

  • Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study). Asghar, Rai; Banajeh, Salem; Egas, Josefina; Hibberd, Patricia; Iqbal, Imran; Katep-Bwalya, Mary; Kundi, Zafarullah; Law, Paul; MacLeod, William; Maulen-Radovan, Irene; Mino, Greta; Saha, Samir; Sempertegui, Fernando; Simon, Jonathon; Santosham, Mathuram; Singhi, Sunit; Thea, Donald M.; Qazi, Shamim // BMJ: British Medical Journal (International Edition);1/12/2008, Vol. 336 Issue 7635, p80 

    Objective: To evaluate whether five days' treatment with injectable ampicillin plus gentamicin compared with chloramphenicol reduces treatment failure in children aged 2-59 months with community acquired very severe pneumonia in low resource settings. Design: Open label randomised controlled...

  • Neumonía no resuelta. Estrategia diagnostica. Rayo, Alfredo Cabrera; Rodríguez, Octavia Plasencia; Burgos, César Quezada; García, Raúl Medellín; Hernández, María Guadalupe Laguna; Asisclo Villagómez Ortiz; Reyes, Raquel Méndez; Gómez, Ricardo Guzmán; León, Sandra Franco // Medicina Interna de Mexico;nov/dic2008, Vol. 24 Issue 6, p418 

    Acute pneumonia is a serious problem of public health. It was defined as an infectious pulmonary process that generally has a clinical stability in its first days of suitable therapy and disappears from the radiographic infiltrations during the following weeks, as the causal microorganism...

  • Clinical signs of pneumonia in children attending a hospital outpatient department in Lesotho. Redd, S. C.; Vreuls, R.; Metsing, M.; Mohobane, P. H.; Patrick, E.; Moteetee, M. // Bulletin of the World Health Organization;1994, Vol. 72 Issue 1, p113 

    To determine the value of clinical findings for the diagnosis of pneumonia, we evaluated 950 children who presented with respiratory illness to the outpatient department of the Queen Elizabeth II Hospital, Maseru, Lesotho. Those children at high risk for pneumonia and a systematically selected...

  • Microbiologic Testing in Severe Community-Acquired Pneumonia. Miller, Karl E. // American Family Physician;6/15/2003, Vol. 67 Issue 12, p2616 

    Discusses the study 'Microbiological Testing and Outcome of Patients With Severe Community-acquired Pneumonia,' by J. Rello et al., from the January 2003 issue of the journal 'Chest.'

  • Review of Intensive Care Unit Admissions for Asthma. Richards, Warren; Lew, Cheryl; Carney, Jean; Platzker, Arnold; Church, Joseph A. // Clinical Pediatrics;Jun1979, Vol. 18 Issue 6, p345 

    A review of ICU admissions for asthma to the Childrens Hospital of Los Angeles was conducted for the period January 1969 through July 1977. The admission rate remained relatively constant during this period. Patients requiring ICU admission tended to be young, intractable severe asthmatics whose...

  • Home oxygen for children: who, how and when? Bolfour-Lynn, I. M.; Primhak, R. A.; Show, B. N. J. // Thorax;Jan2005, Vol. 60 Issue 1, p76 

    This article focuses on specific requirements of home oxygen therapy in children. The prognosis in infancy is usually good; many children only need oxygen for a limited period, although this may be for some years. Almost all children receiving long term oxygen therapy (LTOT) also require...

  • Asthma beliefs among mothers and children from different ethnic origins living in Amsterdam, the Netherlands. van Dellen, Q. M.; van Aalderen, W. M. C.; Bindels, P. J. E.; Öry, F. G.; Bruil, J.; Stronks, K. // BMC Public Health;2008, Vol. 8, p380 

    Background: Doctors and patients hold varying beliefs concerning illness and treatment. Patients' and families' explanatory models (EMs) vary according to personality and sociocultural factors. In a multi-ethnic society, it is becoming increasingly significant that doctors understand the...

  • Ambulatory pulmonary artery pressure monitoring during sleep and exercise in normal individuals and patients with COPD.  // Current Medical Literature: Respiratory Medicine;2003, Vol. 17 Issue 2, p50 

    Discusses the abstract of the article 'Ambulatory pulmonary artery pressure monitoring during sleep and exercise in normal individuals and patients with COPD,' by D.A. Raeside, A. Brown, K.R. Patel et al., published in the Number 57, 2002 issue of the 'Thorax' journal.

  • Oxygen.  // Reactions Weekly;5/21/2011, Issue 1352, p29 

    The article describes the case of an 86-year-old woman with chronic obstructive pulmonary disease (COPD) who developed respiratory failure during treatment with oxygen.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics