TITLE

Protective efficacy of malaria case management and intermittent preventive treatment for preventing malaria mortality in children: a systematic review for the Lives Saved Tool

AUTHOR(S)
Thwing, Julie; Eisele, Thomas P.; Steketee, Richard W.
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011 Supplement 3, Vol. 11 Issue Suppl 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The Lives Saved Tool (LiST) model was developed to estimate the impact of the scale-up of child survival interventions on child mortality. New advances in antimalarials have improved their efficacy of treating uncomplicated and severe malaria. Artemisinin-based combination therapies (ACTs) for uncomplicated Plasmodium falciparum malaria and parenteral or rectal artemisinin or quinine for severe malaria syndromes have been shown to be very effective for the treatment of malaria in children. These interventions are now being considered for inclusion in the LiST model. However, for obvious ethical reasons, their protective efficacy (PE) compared to placebo is unknown and their impact on reducing malaria-attributable mortality has not been quantified. Methods: We performed systematic literature reviews of published studies in P. falciparum endemic settings to determine the protective efficacy (PE) of ACT treatment against malaria deaths among children with uncomplicated malaria, as well as the PE of effective case management including parenteral quinine against malaria deaths among all hospitalized children. As no randomized placebo-controlled trials of malaria treatment have been conducted, we used multiple data sources to ascertain estimates of PE, including a previously performed Delphi estimate for treatment of uncomplicated malaria. Results: Based on multiple data sources, we estimate the PE of ACT treatment of uncomplicated P. falciparum malaria on reducing malaria mortality in children 1-23 months to be 99% (range: 94-100%), and in children 24-59 months to be 97% (range: 86-99%). We estimate the PE of treatment of severe P. falciparum malaria with effective case management including intravenous quinine on reducing malaria mortality in children 1-59 months to be 82% (range: 63-94%) compared to no treatment. Conclusions: This systematic review quantifies the PE of ACT used for treating uncomplicated malaria and effective case management including parenteral quinine for treating severe P. falciparum malaria for preventing malaria mortality in children <5. These data will be used in the Lives Saved Tool (LiST) model for estimating the impact of scaling-up these interventions against malaria. However, in order to estimate the reduction in child mortality due to scale-up of these interventions, it is imperative to develop standardized indicators to measure population coverage of these interventions.
ACCESSION #
60440494

 

Related Articles

  • How Patients Take Malaria Treatment: A Systematic Review of the Literature on Adherence to Antimalarial Drugs. Bruxvoort, Katia; Goodman, Catherine; Kachur, S. Patrick; Schellenberg, David // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Background: High levels of patient adherence to antimalarial treatment are important in ensuring drug effectiveness. To achieve this goal, it is important to understand levels of patient adherence, and the range of study designs and methodological challenges involved in measuring adherence and...

  • Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review. Mvumbi, Dieudonné Makaba; Kayembe, Jean-Marie; Situakibanza, Hippolyte; Bobanga, Thierry L.; Nsibu, Célestin N.; Mvumbi, Georges L.; Melin, Pierrette; De Mol, Patrick; Hayette, Marie-Pierre // Malaria Journal;9/17/2015, Vol. 14 Issue 1, p1 

    Background: Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all drugs available. Monitoring drug resistance is essential for early detection and subsequent...

  • Growing problem of malaria. Marsden, Philip D. // BMJ: British Medical Journal (International Edition);11/25/89, Vol. 299 Issue 6711, p1328 

    Relates the experience of the author on the occurrence of malaria in Brazil. Mortality of children with the disease; Target organs of malaria; Development of antimalarial drug.

  • Patterns of treatment-seeking behaviors among caregivers of febrile young children: a Ugandan multiple case study. Kassam, Rosemin; Sekiwunga, Richard; MacLeod, Duncan; Tembe, Juliet; Liow, Eric // BMC Public Health;2/16/2016, Vol. 16, p1 

    Background: The vast majority of malaria deaths in Uganda occur in children five and under and in rural areas. This study's exploratory case study approach captured unique situations to illustrate special attributes and aspects of treatment-seeking during a malaria...

  • Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. Yakasai, Ahmad M.; Hamza, Muhammad; Dalhat, Mahmood M.; Bello, Musa; Gadanya, Muktar A.; Yaqub, Zuwaira M.; Ibrahim, Daiyabu A.; Hassan-Hanga, Fatimah // Journal of Tropical Medicine (16879686);5/28/2015, Vol. 2015, p1 

    Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was...

  • Current scenario of control of malaria. Singh, Sarman // Tropical Parasitology;Jul2011, Vol. 1 Issue 2, p52 

    The author discusses the scenario of malaria control in India. The author mentions that malaria is a major health problem in the country and several other tropical countries where it causes death of millions of children, adults and pregnant women. The author notes the treatment of malaria which...

  • Efficacy of Pyrimethamine/Sulfadoxine versus Chloroquine for the Treatment of Uncomplicated Falciparum Malaria in Children Aged Under 5 Years. Zheng, W.; Jiang, H.; Xiong, Z.; Jiang, Z.; Chen, H. // Iranian Journal of Parasitology;2013, Vol. 8 Issue 1, p1 

    The children aged under 5 years from vast African areas badly suffer from falciparum malaria and many of them die of this disease. Therapeutic efficacy of anti-malaria drugs, especially pyrimethamine-sulfadoxine (PS) and chloroquine (CQ) to falciparum malaria is frequently evaluated and reported...

  • Feasibility and acceptability of ACT for the community case management of malaria in urban settings in five African sites.  // Malaria Journal;2011, Vol. 10 Issue 1, p240 

    The article discusses a study which examined the feasibility and acceptability of artemisinin-based combination therapy (ACT) for the community case management of malaria in urban settings in five African regions. In all sites, interviews were conducted which revealed that caregivers' knowledge...

  • Evidence Update.  // Africa Health;May2011, Vol. 33 Issue 4, p48 

    The article provides an answer to the question of which artemisinin-based combination therapies (ACTs) are effective in the treatment of uncomplicated P. falciparum malaria.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics