TITLE

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients

AUTHOR(S)
van den Boogaard, Mark; van Swelm, Rachel P. L.; Russel, Frans G. M.; Heemskerk, Suzanne; van der Hoeven, Johannes G.; Masereeuw, Rosalinde; Pickkers, Peter
PUB. DATE
January 2011
SOURCE
Proteome Science;2011, Vol. 9 Issue 1, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Suitable biomarkers associated with the development of delirium are still not known. Urinary proteomics has successfully been applied to identify novel biomarkers associated with various disease states, but its value has not been investigated in delirium patients. Results: In a prospective explorative study hyperactive delirium patients after cardiac surgery were included for urinary proteomic analyses. Delirium patients were matched with non-delirium patients after cardiac surgery on age, gender, severity of illness score, LOS-ICU, Euro-score, C-reactive protein, renal function and aorta clamping time. Urine was collected within 24 hours after the onset of delirium. Matrix-assisted laser desorption/ionisationtime of flight mass spectrometry (MALDI-TOF MS) was applied to detect differences in the urinary proteome associated with delirium in these ICU patients. We included 10 hyperactive delirium and 10 meticulously matched non-delirium post-cardiac surgery patients. No relevant differences in the urinary excretion of proteins could be observed. Conclusions: We conclude that MALDI-TOF MS of urine does not reveal a clear hyperactive delirium proteome fingerprint in ICU patients. Trial Registration: Clinical Trial Register number: NCT00604773
ACCESSION #
60420297

 

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