TITLE

Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance

AUTHOR(S)
Korpi-Hyövälti, Eeva A. L.; Laaksonen, David E.; Schwab, Ursula S.; Vanhapiha, Tarja H.; Vihla, Kristiina R.; Heinonen, Seppo T.; Niskanen, Leo K.
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011, Vol. 11 Issue 1, p179
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: In conjunction with the growing prevalence of obesity and the older age of pregnant women gestational diabetes (GDM) is a major health problem. The aim of the study was to evaluate if a lifestyle intervention since early pregnancy is feasible in improving the glucose tolerance of women at a high-risk for GDM in Finland. Methods: A 75-g oral glucose tolerance test (OGTT) was performed in early pregnancy (n = 102). Women at high risk for GDM (n = 54) were randomized at weeks 8-12 from Apr 2005 to May 2006 to a lifestyle intervention group (n = 27) or to a close follow-up group (n = 27). An OGTT was performed again at weeks 26-28 for the lifestyle intervention and close follow-up groups. Results: The values of the OGTT during the second trimester did not differ between the lifestyle intervention and close follow-up groups. In the lifestyle intervention group three women had GDM in the second trimester and respectively one woman in the close follow up group. Insulin therapy was not required in both groups. The intervention resulted in somewhat lower weight gain 11.4 ± 6.0 kg vs. 13.9 ± 5.1 kg, p = 0.062, adjusted by the prepregnancy weight. Conclusions: Early intervention with an OGTT and simple lifestyle advice is feasible. A more intensive lifestyle intervention did not offer additional benefits with respect to glucose tolerance, although it tended to ameliorate the weight gain. Trial Registration: ClinicalTrials.gov: NCT01130012
ACCESSION #
60407189

 

Related Articles

  • Postprandial glucose levels and gestational diabetes.  // American Family Physician;3/1/1994, Vol. 49 Issue 4, p909 

    Presents an overview of the article on the significance of postprandial glucose test in women with gestational diabetes, published in the `American Journal of Obstetrics and Gynecology' in August 1993. Fasting values; Cost savings from the elimination of the test.

  • Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes. Winhofer, Yvonne; Tura, Andrea; Thomas, Anita; Prikoszovich, Thomas; Winzer, Christine; Pacini, Giovanni; Luger, Anton; Kautzky-Willer, Alexandra // International Journal of Endocrinology;3/22/2015, Vol. 2015, p1 

    Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women...

  • The relationship between glycated hemoglobin and blood glucose levels of 75 and 100 gram oral glucose tolerance test during gestational diabetes diagnosis. Mert, Meral; Purcu, Serhat; Soyluk, Ozlem; Okuturlar, Yildiz; Karakaya, Pinar; Tamer, Gonca; Adas, Mine; Ekin, Murat; Hatipoglu, Sami; Sari Ure, Oznur; Harmankaya, Ozlem; Kumbasar, Abdulbaki // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 8, p13335 

    Objective: The diagnosis of gestational diabetes mellitus (GDM) is an important issue in terms of prevention of maternal and fetal complications. In our study we aimed to evaluate the relation of HbA1c and blood glucose levels of 75 and 50-100 gram oral glucose tolerance test (OGTT) in pregnant...

  • Sialic acid levels in the blood in pregnant women with impaired glucose tolerance test. Findik, Rahime; Yilmaz, Fatma; Yilmaz, Gulsen; Yilmaz, Hinc; Karakaya, Jale // Archives of Gynecology & Obstetrics;Oct2012, Vol. 286 Issue 4, p913 

    Purpose: Gestational diabetes (GDM) is a metabolic disease characterized by the impairment of glucose tolerance during pregnancy. Sialic acid (SA) is a component of glycolipid and glycoproteins found in hormone and enzymes in serum and tissues and high serum SA levels are observed in diabetic...

  • Fasting Plasma Glucose at 24-28 Weeks to Screen for Gestational Diabetes Mellitus: New Evidence From China. Diabetes Care 2013;36:2038-2040. Agarwal, Mukesh M.; Dhatt, Gurdeep S. // Diabetes Care;Feb2014, Vol. 37 Issue 2, pe33 

    The authors comment on a study which is said to support their research indicating the effectiveness of the initial fasting plasma glucose (FPG) results of the oral glucose tolerance test in screening pregnant women for gestational diabetes mellitus in China. They criticize the researchers' use...

  • Dietary fat and gestational hyperglycaemia. Bo, S.; Menato, G.; Lezo, A.; A.Signorile; Berdelli, C.; De Michieli, F.; Massobrio, M.; Pagano, G. // Diabetologia;Aug2001, Vol. 44 Issue 8, p972 

    Aims/hypothesis: The purpose of this study was to investigate the relation between life-style habits and glucose abnormalities in Caucasian women with and without conventional risk factors for gestational diabetes. Methods: A total of 126 pregnant women with gestational diabetes, 84 with...

  • 1-Hour OGTT Plasma Glucose as a Marker of Progressive Deterioration of Insulin Secretion and Action in Pregnant. Ghio, Alessandra; Seghieri, Giuseppe; Lencioni, Cristina; Anichini, Roberto; Bertolotto, Alessandra; De Bellis, Alessandra; Resi, Veronica; Lacaria, Emilia; Del Prato, Stefano; Di Cianni, Graziano // International Journal of Endocrinology;2012, p1 

    Considering old GDM diagnostic criteria, alterations in insulin secretion and action are present in women with GDM as well as in women with one abnormal value (OAV) during OGTT. Our aim is to assess if changes in insulin action and secretion during pregnancy are related to 1-hour plasma glucose...

  • Comparison of screening for gestational diabetes mellitus by oral glucose tolerance tests done in the non-fasting (random) and fasting states. Mohan, Viswanathan; Mahalakshmi, Manni; Bhavadharini, Balaji; Maheswari, Kumar; Kalaiyarasi, Gunasekaran; Anjana, Ranjit; Uma, Ram; Usha, Sriram; Deepa, Mohan; Unnikrishnan, Ranjit; Pastakia, Sonak; Malanda, Belma; Belton, Anne; Kayal, Arivudainambi // Acta Diabetologica;Dec2014, Vol. 51 Issue 6, p1007 

    Aim: The Diabetes in Pregnancy Study Group of India (DIPSI) guidelines recommend the non-fasting 75-g oral glucose tolerance test (OGTT) as a single-step screening and diagnostic test for gestational diabetes mellitus (GDM). The aim of this study was to compare the DIPSI criteria with the World...

  • Fasting Plasma Glucose at 24-28 Weeks to Screen for Gestational Diabetes Mellitus: New Evidence From China. Diabetes Care 2013;36:2038-2040. Wei-wei Zhu; Hui-xia Yang; Kapur, Anil // Diabetes Care;Feb2014, Vol. 37 Issue 2, pe34 

    A response to a commentary on the authors' study indicating the effectiveness of the initial fasting plasma glucose (FPG) results of the oral glucose tolerance test in screening pregnant women for gestational diabetes mellitus in China, is presented. They discuss the use of the FPG screening...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics