TITLE

Frontiers of X-ray spectromicroscopy in biology and medicine: Gadolinium in brain cancer

AUTHOR(S)
De Stasio, Gelsomina; Gilbert, B.; Perfetti, P.; Margaritondo, G.; Mercanti, D.; Ciotti, M. T.; Casalbore, P.; Larocca, L. M.; Rinelli, A.; Pallini, R.
PUB. DATE
February 2000
SOURCE
AIP Conference Proceedings;2000, Vol. 506 Issue 1, p577
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We present the first feasibility test of spectromicroscopy on the microlocalization of gadolinium in brain cancer tissue. A gadolinium compound was injected to the patients before the brain tumor was extracted with surgery, and we looked for Gd in the tumor tissue. The goal of the experiment was to understand if Gd Neutron Capture Therapy (GdNCT) is viable for clinical tests, i.e. if there is enough Gd, and it is localized near the nuclei of tumor cells. The experiments were performed using the MEPHISTO X-ray PhotoElectron Emission Microscope (X-PEEM) at the Wisconsin Synchrotron Radiation Center. The present results demonstrate the feasibility of the experiment, and suggest how to improve the sample preparation and data acquisition to achieve the goal. © 2000 American Institute of Physics.
ACCESSION #
6029478

 

Related Articles

  • Feasibility study of clinical trial for breast cancer and lung cancer at Indian sites. Mehta, Varun M.; Bhatt, Arun D. // Perspectives in Clinical Research;Oct-Dec2013, Vol. 4 Issue 4, p211 

    Objective: The objective of this study was to conduct feasibility study of phase III breast and lung cancer clinical trials in India. Materials and Methods: Study synopsis and feasibility questionnaire were mailed to 300 oncologists for each indication. Criteria of selection were enrolment of...

  • Focal Therapy for Prostate Cancer Safe.  // Renal & Urology News;Feb2013, Vol. 12 Issue 2, p14 

    The article reports on the study published online in "European Urology" which explored the feasibility of focal therapy for localized prostate cancer in France.

  • Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: feasibility study. Sheinerman, Kira S.; Tsivinsky, Vladimir G.; Umansky, Samuil R. // Journal of Translational Medicine;2013, Vol. 11 Issue 1, p2 

    Background Early disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach - Universal Screening Test (UST) for the detection of pathological processes in a particular...

  • Laparoscopic spleen-preserving No. 10 lymph node dissection for advanced proximal gastric cancer in left approach: a new operation procedure. Wang Jia-Bin; Huang Chang-Ming; Zheng Chao-Hui; Li Ping; Xie Jian-Wei; Lin Jian-Xian // World Journal of Surgical Oncology;2012, Vol. 10 Issue 1, p241 

    Background: To explore the feasibility of laparoscopic spleen-preserving No. 10 lymph node dissection in a left-sided approach for advanced proximal gastric cancer. Methods: The clinical data of 32 patients with advanced proximal gastric cancer who underwent laparoscopic spleen-preserving No. 10...

  • Feasibility and Acceptance of a Pharmacist-Run Tele-oncology Service for Chemotherapy-Induced Nausea and Vomiting in Ambulatory Cancer Patients. Yap, Kevin Y.-L.; Low, Hui X.; Koh, Ken S.; Un, Matthew; Shih, Vivianne; Chan, Alexandre // Telemedicine & e-Health;May2013, Vol. 19 Issue 5, p387 

    Background: The use of telemedicine for cancer patients is limited, particularly in Asia. These patients need to be monitored because more are being treated as outpatients, so that any treatment-related side effects can be managed. We assessed the feasibility and acceptance of a pharmacist-run...

  • The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery.  // BMC Surgery;2011, Vol. 11 Issue 1, p34 

    The article focuses on a study that reviewed the CARTS study which is a multicenter feasibility study for rectal cancer in the distal rectum. Transanal Endoscopic Microsurgery (TEM) will be performed for 8-10 weeks after preoperative treatment depending on the clinical response. It stated that...

  • Radiofrequency Ablation of Breast Cancer. Singletary, S. Eva // American Surgeon;Jan2003, Vol. 69 Issue 1, p37 

    Radiofrequency ablation (RFA) is currently under study as a candidate for nonsurgical removal or destruction of breast tumors. RFA of solid tumors is produced by frictional heating caused when ions in the tissue attempt to follow the changing directions of a high-frequency alternating current....

  • Circulating tumour cells in breast cancer. Krawczyk, Natalia; Banys, Malgorzata; Hartkopf, Andreas; Hagenbeck, Carsten; Melcher, Carola; Fehm, Tanja // Ecancermedicalscience;2013, Vol. 7 Issue 334-360, p1 

    Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced...

  • Novel Multisensor Probe for Monitoring Bladder Temperature During Locoregional Chemohyperthermia for Nonmuscle-Invasive Bladder Cancer: Technical Feasibility Study. Cordeiro, Ernesto R.; Geijsen, Debby E.; Zum Vörde Sive Vörding, Paul J.; Schooneveldt, Gerben; Sijbrands, Jan; Hulshof, Maarten C.; de la Rosette, Jean; de Reijke, Theo M.; Crezee, Hans // Journal of Endourology;Dec2013, Vol. 27 Issue 12, p1504 

    Background and Purpose: The effectiveness of locoregional hyperthermia combined with intravesical instillation of mitomycin C to reduce the risk of recurrence and progression of intermediate- and high-risk nonmuscle-invasive bladder cancer is currently investigated in clinical trials. Clinically...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics