Bifurcation diagrams of frequency dependence of repolarization during long QT syndrome using the Luo-Rudy model of cardiac repolarization

Bondarenko, V. E.; Doedel, E. J.; Rasmusson, R. L.
February 2000
AIP Conference Proceedings;2000, Vol. 502 Issue 1, p175
Academic Journal
We applied bifurcation analysis to the Luo-Rudy model of the guinea pig cardiac ventricular cell to investigate the behavior of repolarization in response to a simulated form of inherited arrhythmia, long QT syndrome. In this paper, we simulate pathological changes in cardiac repolarization through reductions in I[sub Kr]. Decreased expression of this current has been linked to an inherited form of long QT syndrome which results in a high mortality, presumably due to sudden cardiac death from ventricular fibrillation. © 2000 American Institute of Physics.


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