Structural and dynamic properties of bulky ligand derivatives of hemeproteins

Sanfratello, Vincenzo; Boffi, Alberto; Cupane, Antonio; Leone, Maurizio
April 2000
AIP Conference Proceedings;2000, Vol. 513 Issue 1, p218
Academic Journal
We report the visible absorption spectra of nicotinate and carbonmonoxy derivatives of soybean leghemoglobin-a and horse myoglobin. The fine structure of the optical bands was taken into account by a deconvolution procedure in terms of vibrational Condon and non-Condon couplings of the heme normal modes to the Q electronic transitions, in the framework of the Herzberg-Teller approximation. The local dynamics of the heme pocket for all the derivatives have been investigated through the temperature dependence, down to cryogenic temperatures, of the spectral line broadening. The results indicate that leghemoglobin-a better accommodate, with respect to horse myoglobin, the structural distortions imposed within the heme pocket by the bulky nicotinate group. The comparative study of the carbonmonoxy derivatives suggests that nicotinate induces smaller heterogeneities and smaller anharmonicities for both proteins. © 2000 American Institute of Physics.


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