TITLE

Influence of trehalose on conformational and dynamical properties of Poly(Ethylene Oxide) in water

AUTHOR(S)
Villari, V.; Branca, C.; Faraone, A.; Magazu`, S.; Maisano, G.; Migliardo, P.
PUB. DATE
April 2000
SOURCE
AIP Conference Proceedings;2000, Vol. 513 Issue 1, p250
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This paper reports the results of a study on Poly(Ethylene Oxide)/trehalose/water mixtures performed by Photon Correlation Spectroscopy. The chemical structure of the polymer, simpler than that of proteins and its helical conformation in water, constitute a useful starting point for understanding the more complex protein/trehalose/water interactions. The obtained findings support the “water-replacement” hypothesis, indicating that a direct polymer-trehalose interaction occurs. Furthermore, trehalose is shown to affect the swelling properties of the polymer with temperature, stabilizing its conformation. © 2000 American Institute of Physics.
ACCESSION #
6028438

 

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