Dynamics of cultured neuronal networks

Kawana, Akio
February 2000
AIP Conference Proceedings;2000, Vol. 501 Issue 1, p240
Academic Journal
Experimental investigation of the dynamics of biological networks is a fundamental step in understanding how the nervous system works. Spontaneous and evoked activity in cultured networks of cortical neurons has been investigated by using a multisite recording technique with planar electrode arrays. Spontaneous activity of the developing networks showed three different types of dynamics according to their developmental stages. At early stages, they showed spatiotemporally random activity. This then developed into a periodic synchronized pattern. Finally a complex higher-order activity pattern emerged which remained stable with further development, and appeared to be the final intrinsic mode of firing. These dynamical changes were mainly due to the development of connectivity of synapses and of inhibitory synapses. From the viewpoint of physiology, these dynamical changes seem to play an important role in development of the networks. © 2000 American Institute of Physics.


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