TITLE

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

AUTHOR(S)
Altun, Tugba; Jindal, Sangita; Greenseid, Keri; Shu, Jun; Pal, Lubna
PUB. DATE
March 2011
SOURCE
Journal of Assisted Reproduction & Genetics;Mar2011, Vol. 28 Issue 3, p245
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. Methods: Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA ( n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. Results: Significant positive correlations were observed between IL-6 with age ( p = 0.035), and IL-6 with estradiol on the day of hCG ( p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy ( p = 0.045). Conclusions: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.
ACCESSION #
60173796

 

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