Emergence of raltegravir-resistant HIV-1 in the central nervous system

Watanabe, K.; Honda, M.; Watanabe, T.; Tsukada, K.; Teruya, K.; Kikuchi, Y.; Oka, S.; Gatanaga, H.
December 2010
International Journal of STD & AIDS;Dec2010, Vol. 21 Issue 12, p840
Academic Journal
Integrase inhibitor-resistant HIV-1 was detected in the cerebrospinal fluid, but not in the plasma of a 42-year-old man with HIV encephalopathy treated with a raltegravir (RAL)-containing regimen. Raltegravir resistance may develop in the central nervous system when the virus is already multi-drug resistant because of different penetration into cerebrospinal fluid of individual antiretroviral agents.


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