Jarisch-Herxheimer reaction among syphilis patients in Rio de Janeiro, Brazil

Miller, W. M.; Gorini, F.; Botelho, G.; Moreira, C.; Barbosa, A. P.; Pinto, A. R. S. B.; Dias, M. F.; Souza, L. M.; Asensi, M. D.; da Costa Nery, J. A.
December 2010
International Journal of STD & AIDS;Dec2010, Vol. 21 Issue 12, p806
Academic Journal
Jarisch-Herxheimer reaction (JHR) is a syndrome observed after antimicrobial treatment of some infectious diseases. The syndrome has clinical characteristics of an inflammatory reaction to antibiotic treatment. A prospective study of patients with a clinical and laboratory diagnosis of syphilis was conducted at a sexually transmitted diseases clinic in Rio de Janeiro, Brazil. Patients were treated with benzathine penicillin and observed for the JHR. A total of 115 patients were included in this study. Fifty-one patients (44%) had secondary syphilis; 37 (32%), primary; 26 (23%), latent; and one (1 %), tertiary syphilis. Ten patients (9%) developed the JHR. All JHRs occurred in patients with secondary and latent syphilis. No patients experienced an allergic reaction to penicillin. The JHR occurred less frequently than in previous studies. It is important that health-care professionals recognize the clinical characteristics of the JHR so that it is not misinterpreted as an allergic reaction to penicillin.


Related Articles

  • QUICK CURE FOR SYMPHILIS.  // Ebony;Feb1948, Vol. 3 Issue 4, p43 

    The article offers information on quick cure for syphilis from penicillin. It reports that syphilis can be cured within nine days. It informs about Intensive Treatment Center in Chicago, Illinois where venereal disease (VD) were being diagnosed. It mentions about the VD detectives who track down...

  • UK National Audit of Early Syphilis Management. Clinics audit: screening for and management of early syphilis. McClean, Hugo; Daniels, David; Carne, Chris; Bunting, Paul; Miller, Rob // International Journal of STD & AIDS;May2006, Vol. 17 Issue 5, p344 

    Data were provided by 131 clinics, and 56% of cases were managed in clinics in the London regions in 2003. Three clinics (2%) do not routinely screen new patients for syphilis, and 28 clinics (21%) do not routinely screen 'rebook' patients who have had a new partner. More than 80% of clinics...

  • Awareness of the cutaneous manifestations of syphilis helps ensure prompt diagnosis and treatment.  // Drugs & Therapy Perspectives;May2007, Vol. 23 Issue 5, p19 

    The number of syphilis cases has increased in the last decade and largely involves men who have sex with men, many of whom are infected with HIV. Clinicians should be aware of the many manifestations of syphilis and the difficulties in its diagnosis and management. In the primary stage,...

  • AZITHROMYCIN FAILURES REINFORCE PENICILLIN AS PREFERRED DRUG FOR SYPHILIS: CDC. Kaye, Donald // Clinical Infectious Diseases;5/1/2004, Vol. 38 Issue 9, p3 

    A recent report of syphilis patients in San Francisco, California who did not respond to azithromycin reinforces current recommendations that penicillin is the preferred agent for this disease, according to the U.S. Centers for Disease Control and Prevention (CDC). Although penicillin remains...

  • Syphilis Treatment Response Among HIV-Discordant Couples in Zambia and Rwanda. Dionne-Odom, Jodie; Karita, Etienne; Kilembe, William; Henderson, Faith; Vwalika, Bellington; Bayingana, Roger; Li, Zhigang; Mulenga, Joseph; Chomba, Elwyn; del Rio, Carlos; Khu, Naw Htee; Tichacek, Amanda; Allen, Susan // Clinical Infectious Diseases;Jun2013, Vol. 56 Issue 12, p1829 

    In 2 large human immunodeficiency virus (HIV)–discordant couple cohorts in Africa, time to treatment response after penicillin therapy for a positive rapid plasma reagin test result was similar irrespective of HIV status. Despite effective therapy, serofast state and syphilis reinfection...

  • Syphilitic Chancres of the Mouth: Three Cases. Ramoni, Stefano; Cusini, Marco; Gaiani, Francesca; Crosti, Carlo // Acta Dermato-Venereologica;2009, Vol. 89 Issue 6, p648 

    The article presents case studies heterosexual man and bisexual man due to the painless, indurated ulcerative lesions of the oral mucosa known as syphilitic chancre. The patients underwent several examinations and found out that they engaged in unprotected receptive orogenital contact with...

  • Take One. Roth, Chelsea // Word (Word Publications - Ted Fleischaker);Dec2008, p68 

    The article provides information on syphilis, a sexually transmitted disease (STD) caused by a bacterium. The most common victims of syphilis infections are men who have sex with men. The symptoms of the disease include having a rash, fever, sore throat and muscle aches. Penicillin is...

  • Syphilis: Should We Change the Treatment of Choice? Osborne, Newton G. // Journal of Gynecologic Surgery;Sep2008, Vol. 24 Issue 3, p131 

    The article addresses the need to change the treatment of choice for syphilis. Syphilis is caused by infection with Treponema pallidum. The preferred treatment for syphilis has been intramuscular benzathine penicillin G. A study which examines the effectiveness and safety of oral azithromycin...

  • 'Rare' syphilis set to make a comeback. Morris, David // GP: General Practitioner;3/24/2003, p67 

    The article reports that the incidence of syphilis in the Great Britain is on the rise again. Transmission of T pallidum occurs principally through sexual contact, when the organism enters the body across mucous membranes or through skin abrasions. After primary infection, a firm papule...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics