Maternal selenium status during early gestation and risk for preterm birth

Rayman, Margaret P.; Wijnen, Hennie; Vader, Huib; Kooistra, Libbe; Pop, Victor
March 2011
CMAJ: Canadian Medical Association Journal;3/22/2011, Vol. 183 Issue 5, p549
Academic Journal
Background: Preterm birth occurs in 5%-13% of pregnancies. It is a leading cause of perinatal mortality and morbidity and has adverse long-term consequences for the health of the child. Because of the role selenium plays in attenuating inflammation, and because low concentrations of selenium have been found in women with preeclampsia, we hypothesized that low maternal selenium status during early gestation would increase the risk of preterm birth. Methods: White Dutch women with a singleton pregnancy (n = 1197) were followed prospectively from 12 weeks' gestation. Women with thyroid disease or type 1 diabetes were excluded. At delivery, 1129 women had complete birth-outcome data. Serum concentrations of selenium were measured during the 12th week of pregnancy. Deliveries were classified as preterm or term, and preterm births were subcategorized as iatrogenic, spontaneous or the result of premature rupture of the membranes. Results: Of the 60 women (5.3%) who had a preterm birth, 21 had premature rupture of the membranes and 13 had preeclampsia. The serum selenium concentration at 12 weeks' gestation was significantly lower among women who had a preterm birth than among those who delivered at term (mean 0.96 [standard deviation (SD) 0.14] µmol/L v. 1.02 [SD 0.13] µmol/L; t = 2.9, p = 0.001). Women were grouped by quartile of serum selenium concentration at 12 weeks' gestation. The number of women who had a preterm birth significantly differed by quartile (X2 = 8.01, 3 degrees of freedom], p < 0.05). Women in the lowest quartile of serum selenium had twice the risk of preterm birth as women in the upper three quartiles, even after adjustment for the occurrence of preeclampsia (adjusted odds ratio 2.18, 95% confidence interval 1.25-3.77). Interpretation: Having low serum selenium at the end of the first trimester was related to preterm birth and was independent of the mother having preeclampsia. Low maternal selenium status during early gestation may increase the risk of preterm premature rupture of the membranes, which is a major cause of preterm birth.


Related Articles

  • Selenium prevents pre-eclampsia. Robinson, Jean // AIMS Journal;2004, Vol. 16 Issue 2, p15 

    Determines the association of low selenium with an increased risk of pre-eclampsia. Average level of selenium in the pre-eclampsia group; Cause of maternal death; Importance of selenium in human diet.

  • Toenails and selenium: preventing pre-eclampsia. Robinson, Jean // British Journal of Midwifery;Jun2004, Vol. 12 Issue 6, p366 

    Focuses on the link between selenium deficiency in pregnancy to pre-eclampsia. Role of peroxynitrite in pre-eclampsia; Findings of a study of pregnant women which examined selenium levels in their toenails; Sources of selenium.

  • Prevalence and risk factors associated with preterm birth in Ardabil, Iran. Alijahan, Rahele; Hazrati, Sadegh; Mirzarahimi, Mehrdad; Pourfani, Farhad; Had, Peymaneh Ahmadi // Iranian Journal of Reproductive Medicine;Jan2014, Vol. 12 Issue 1, p47 

    Background: Preterm birth is a leading cause of perinatal mortality and long-term morbidity as well as the long-term health consequences and cognitive outcomes. Objective: Present study was conducted to determine prevalence and risk factors associated with preterm birth in Ardabil, Iran....

  • The Impact of Hydramnios on Pregnancy Outcome in Twin Gestations. Orhan, Ayfer; Kurzel, Richard B; Istwan, Niki B; Rhea, Debbie; Burgess, Eric; Stanziano, Gary // Journal of Perinatology;Jan2005, Vol. 25 Issue 1, p8 

    OBJECTIVE:: To compare pregnancy outcome in twin pregnancies with and without hydramnios. STUDY DESIGN:: A database of women receiving outpatient preterm labor surveillance services was studied for the period 1988 to 2002. Included were women with twin gestations under 30 weeks'gestation at...

  • The Prevalence of Chronic Deciduitis in Cases of Preterm Labor without Clinical Chorioamnionitis. Edmondson, Nadeen; Bocking, Alan; Machin, Geoffrey; Rizek, Rose; Watson, Carole; Keating, Sarah // Pediatric & Developmental Pathology;Jan/Feb2009, Vol. 12 Issue 1, p16 

    Preterm labor is a major cause of perinatal mortality and morbidity, and in approximately 30% of cases a clinical cause is not identified. Acute chorioamnionitis is found histologically in a significant percentage of placentas from preterm deliveries, and the mother is often asymptomatic....

  • Preterm Labor. WEISMILLER, DAVID G. // American Family Physician;2/1/1999, Vol. 59 Issue 3, p593 

    Discusses a standardized approach to the diagnosis and treatment of preterm labor. Risk factors for preterm labor; Significance of cervical assessment; Background of transvaginal ultrasound examination; Strategies for the management of preterm labor.

  • u High-Risk" Pregnancies and Perinatal Mortality.  // Clinical Pediatrics;Nov1967, Vol. 6 Issue 11, p611 

    Outlines key findings of the London report “Standards of Obstetric Care: The Report of the North-west Metropolitan Regional Obstetric Survey, 1962-64.” Analysis of a mass of clinical data from "high risk" types of obstetric cases, including breech presentations, multiple pregnancies,...

  • Improved Pregnancy Outcome in Type 1 Diabetic Women With Microalbuminuria or Diabetic Nephropathy. Nielsen, Lene Ringholm; Damm, Peter; Mathiesen, Elisabeth R. // Diabetes Care;Jan2009, Vol. 32 Issue 1, p38 

    OBJECTIVE -- To describe pregnancy outcome in type 1 diabetic women with normoalbuminuria, microalbuminuria, or diabetic nephropathy after implementation of an intensified antihypertensive therapeutic strategy. RESEARCH DESIGN AND METHODS-- Prospective study of 117 pregnant women with type 1...

  • Preterm Labour: An Overview of Current and Emerging Therapeutics. Matthias K. Schwarz; Patrick Page // Current Medicinal Chemistry;Aug2003, Vol. 10 Issue 15, p1441 

    Preterm labour is a major cause of perinatal mortality and morbidity. However, during the past 40 years of clinical studies and despite the use of multiple therapeutic agents, the rate of preterm birth has not drastically declined. In 1991, it was estimated that in the US approximately 116,000...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics