TITLE

Bare, Bio-Active and Hydrogel-Coated Coils for Endovascular Treatment of Experimentally Induced Aneurysms

AUTHOR(S)
Reinges, M. H. T.; Krings, T.; Drexler, A. Y.; Ludolph, A.; Sellhaus, B.; Bovi, M.; Geibprasert, S.; Agid, R.; Scherer, K.; Hans, F. J.
PUB. DATE
June 2010
SOURCE
Interventional Neuroradiology;giu2010, Vol. 16 Issue 2, p139
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endovascular treatments of cerebral aneurysms with bare platinum coils have a higher rate of recurrence compared to surgical clipping. This may be related to failed vessel wall reconstruction since histological and scanning electron microscopy results following embolization failed to demonstrate neoendothelialization over the aneurysm neck. The present study tried to elucidate whether the use of modified coils resulted in a better rate of reconstructing the vessel wall over the aneurysm neck in experimental aneurysms. Aneurysms were created in 20 rabbits by intraluminal elastase incubation of the common carotid artery. Five animals each were assigned to the following groups: untreated, bare platinum coils, bioactive coils with polyglycolic/polylactic acid coating, and hydrogel-coated platinum coils. After 12 months, angiography, histology and scanning electron microscopy was performed. No neoendothelial layer was visualized in the bioactive and bare coil groups with a tendency to an increased layering of fibroblasts along the bioactive coils at the aneurysm fundus. However, at the aneurysm neck perfused clefts were present and although a thin fibrinous layer was present over some coils, no bridging neointimal or neoendothial layer was noted over different coils. Following loose Hydro gel coiling, a complete obliteration of the aneurysm was present with neoendothelialization present over different coil loops. The study demonstrates that with surface coil modifications complete and stable aneurysm obliteration may become possible. A smooth and dense surface over the aneurysm neck may be necessary for endothelial cells to bridge the aneurysm neck and to lead to vessel wall reconstruction.
ACCESSION #
60144868

 

Related Articles

  • Infectious intracranial aneurysms in the pediatric population: endovascular treatment with Onyx. Christopher Eddleman; Daniel Surdell; Arthur DiPatri; Tadanori Tomita // Child's Nervous System;Aug2008, Vol. 24 Issue 8, p909 

    Abstract Objects  Infectious intracranial aneurysms present a treatment challenge in the pediatric population. Current endovascular strategies and tools have been developed, which make treatment of infectious intracranial aneurysms with liquid embolics safe and effective. This study...

  • Um Caso de Sucesso no Tratamento Concomitante de Rotura de Aneurisma Intracraniano e Aneurisma Visceral. DIOGO, Cláudia; BALTAZAR, José; FERNANDES, Mário // Acta Medica Portuguesa;nov-dez2012, Vol. 25 Issue 6, p465 

    The association between intracranial and visceral aneurysms is very rare, with a bad prognosis. The rupture usually appears in the Emergency Room, and it implies an immediate treatment. We describe the case of a woman with rupture of an anterior communicant artery aneurysm and rupture of a...

  • Aneurysm embolization grade: a predictive tool for aneurysm recurrence after coil embolization. Singla, Amit; Villwock, Mark; Jacobsen, Walter; Deshaies, Eric // Acta Neurochirurgica;Feb2013, Vol. 155 Issue 2, p231 

    Background: Coil embolization has gained importance in the management of intracranial aneurysms over the past decade. However, the recurrence risk after embolization mandates closer follow-up than surgical clip ligation. Currently, there is no reliable system for predicting aneurysm sac...

  • Undulating microcatheter tip motion with respiratory cycle during intracranial aneurysm embolization: description of a case and strategy for its mitigation. X Chen, James; Gottschalk, Allan; Kathuria, Sudhir; Gandhi, Dheeraj // Journal of NeuroInterventional Surgery;May2012, Vol. 4 Issue 3, p1 

    The present report describes a technique for mitigating respiration-related microcatheter motion during endovascular aneurysm treatment by modulating ventilator settings. A rare phenomenon of microcatheter tip movement related to respiration is demonstrated. An adjustment of tidal volume and...

  • Novel use of the pipeline embolization device for reperfusion of the middle cerebral artery post surgical aneurysm clipping. MacKenzie Nyberg, Eric; Chaudry, M. Imran; Turk, Aquilla S.; Turner, Raymond D. // Journal of NeuroInterventional Surgery;Sep2013, Vol. 5 Issue 5, p1 

    We describe a case in which elective surgical clipping of an internal carotid artery terminus aneurysm resulted in compromised flow through the ipsilateral middle cerebral artery (MCA). Reperfusion was salvaged the following day with novel use of the pipeline embolization device to buttress open...

  • Aneurysms.  // Interventional Neuroradiology;Mar/Apr2014, Vol. 20 Issue 2, p157 

    The article presents abstracts on topics including embolization of cerebral aneurysms, treatment of aneurysm on distal intracranial artery, and LUNA Aneurysm Embolization System.

  • Retrievable stent for migrated coil removal: Literature review. Xin-Pu Chen; Zheng Feng Wang; Zhai Guang; Xian-Zhi Liu // Neurology India;Nov/Dec2015, Vol. 63 Issue 6, p992 

    A letter to the editor which looks at literature associated with the use of retrievable stent for migrated coil removal, which is a serious complication during endovascular embolization of intracranial aneurysms is presented.

  • Retrograde trans-anterior communicating artery rescue of unopened Pipeline Embolization Device with balloon dilation: complication management. Navarro, Ramon; Hanel, Ricardo A.; Jang Yoon; Miller, David A.; Dixon, Tanya; Tawk, Rabih G. // Journal of NeuroInterventional Surgery;Feb2015, Vol. 7 Issue 2, p1 

    As the use of the Pipeline Embolization Device (PED) for the treatment of complex intracranial aneurysms rises, knowledge about complications continues to accumulate amidt a paucity of reports on techniques and rescue strategies. We describe the case of a 70-year-old woman who presented...

  • Endovascular Treatment Accounts for a Change in Brain Arteriovenous Malformation Natural History Risk. Lv, X.; Wu, Z.; Jiang, C.; Li, Y.; Yang, X.; Zhang, Y.; Lv, M.; Zhang, N. // Interventional Neuroradiology;giu2010, Vol. 16 Issue 2, p127 

    This study estimated the risk and rates of intracranial hemorrhage (ICH) in patients harboring brain arteriovenous malformation (BAVM) after endovascular embolization. One hundred and forty-four consecutive patients with BAVM treated with endovascular embolization between 1998 and 2003 were...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics