Hypertrophic Obstructive Cardiomyopathy, Bleeding History, and Acquired von Willebrand Syndrome: Response to Septal Myectomy

March 2011
Mayo Clinic Proceedings;Mar2011, Vol. 86 Issue 3, p219
Academic Journal
Bleeding with severe aortlc stenosis is linked to acquired von Wiliebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight muitimers. We report outcomes In 5 patients with symptomatic obstructive hypertrophic cardlomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgicai bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients under- went surgical septal myectomy with resolution of acquired von Willebrand syndrome. Mayo Clin Proc. 2011;86(3):219.224


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