Effects of clinical decision support on initial dosing and monitoring of tobramycin and amikacin

Cox, Zachary L.; Nelsen, Cori L.; Waitman, Lemuel R.; McCoy, Jacob A.; Peterson, Josh F.
April 2011
American Journal of Health-System Pharmacy;4/1/2011, Vol. 68 Issue 7, p624
Academic Journal
The article discusses a study at the Vanderbilt University Medical Center (VUMC) on the impact of clinical decision support (CDS) on initial dosing and monitoring in amikacin and tobramycin therapy. The study reported an improved rate of achieving target trough serum drug concentrations with CDS when compared with standard dosing. Details pertaining to the methods and the design of the aminoglycoside advisor embedded in a computerized prescriber-order-entry (CPOE) system are also discussed.


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