TITLE

Association of Kidney Function and Metabolic Risk Factors With Density of Glomeruli on Renal Biopsy Samples From Living Donors

AUTHOR(S)
Rule, Andrew D.; Semret, Merfake H.; Amer, Hatem; Cornell, Lynn D.; Taler, Sandra J.; Lieske, John C.; Melton III, L. Joseph; Stegall, Mark D.; Textor, Stephen C.; Kremers, Walter K.; Lerman, Lilach O.
PUB. DATE
April 2011
SOURCE
Mayo Clinic Proceedings;Apr2011, Vol. 86 Issue 4, p282
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults. PATIENTS AND METHODS: This study compared glomerular density with predonation kidney function, blood pressure, and metabolic risk factors In living kidney donors at Mayo Clinic in Rochester, MN, from May 10, 1999, to February 4, 2009. During Implantation of the kidney allograft, an 18-gauge core needle biopsy sample of the renal cortex was obtained, sectioned, and examined by pathologists. Glomerular density was determined by the number of glomeruli (normal and sclerotic) divided by area of cortex. RESULTS: The study sample of 1046 kidney donors had a mean of 21 glomeruli (0.8 sclerotic glomeruli) and a glomerular density of 2.3 glomeruli per square millimeter. In a subset of 54 donors, glomerular density Inversely correlated with the mean glomerular area (r,=-0.28). independent predictors of decreased glomerular density were older age, increased glomerular filtration rate, family history of end-stage renal disease, increased serum uric acid, and Increased body mass index, Increased urine albumin excretion, hypertension, decreased high-density lipoprotein cholesterol, and metabolic syndrome were also associated with decreased glomerular density after age-sex adjustment. These associations were not explained by the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis, or arteriosclerosis on the renal biopsy sample. In older donors, decreased glomerular density was attenuated by an increased prevalence of glomerulosclerosis and tubular atrophy. CONCLUSION: Decreased glomerular density is associated with many different kidney function and metabolic risk factors among relatively healthy adults and may represent an early state of increased risk of parenchymal Injury.
ACCESSION #
59803639

 

Related Articles

  • Estimated Glomerular Filtration Rate and Albuminuria as Predictors of Outcomes in Patients With High Cardiovascular Risk. Clase, Catherine M.; Gao, Peggy; Tobe, Sheldon W.; McQueen, Matthew J.; Grosshennig, Anja; Teo, Koon K.; Yusuf, Salim; Mann, Johannes F.E. // Annals of Internal Medicine;3/1/2011, Vol. 154 Issue 5, p310 

    Background: Glomerular filtration rate and albuminuria are risk factors for cardiovascular disease and markers of renal function. Objective: To examine the contribution of estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio beyond that of traditional cardiovascular...

  • THE IMMUNOEXPRESSION OF GLOMERULAR NF-κB IN PROTEINURIC PATIENTS WITH PROLIFERATIVE AND NON-PROLIFERATIVE GLOMERULOPATHIES. DANILEWICZ, MARIAN; WĄGROWSKA-DANILEWICZ, MAŁGORZATA // Polish Journal of Pathology: Official Journal of the Polish Soci;2013, Issue 2, p78 

    Recent studies suggest that NF-κB activation plays an essential role in the activation of mesangial cells and macrophages through the transcriptional induction of inflammatory mediators of glomerular inflammation and injury. The aim of the present study was to determine, using an image...

  • Glomerular filtration rate estimation and mortality in an elderly population. Y. Maaravi; M. Bursztyn; R. Hammerman-Rozenberg; J. Stessman // QJM: An International Journal of Medicine;Jun2007, Vol. 100 Issue 7, p441 

    Background: Few studies have addressed the link between minor renal dysfunction and mortality in the elderly. Aim: To compare three equations for estimated GFR (eGFR) in assessing renal dysfunction and predicting mortality in an elderly population. Design: Longitudinal observational study....

  • Susceptibility of glomerular filtration rate estimations to variations in creatinine methodology: a study in older patients. Lamb, Edmund J; Wood, Joanna; Stowe, Helen J; O'Riordan, Shelagh E; Webb, Michelle C; Dalton, R Neil // Annals of Clinical Biochemistry;Jan2005, Vol. 42 Issue 1, p11 

    Background: It is recommended that measurement of serum creatinine should be supplemented with a creatinine-based estimation of glomerular filtration rate (GFR). The influence of creatinine methodology on these estimates is not always appreciated. We have studied differences in creatinine...

  • Performance of Serum Cystatin-C Versus Serum Creatinine in Subjects With Type 1 Diabetes. Buysschaert, Martin; Joudi, Ihab; Wallemacq, Pierre; Hermans, Michel P. // Diabetes Care;Apr2003, Vol. 26 Issue 4, p1320 

    Presents a letter to the editor regarding how the glomerular filtration rate is considered the best market of renal function.

  • ESTIMATED GLOMERULAR FILTRATION RATE (EGFR).  // Bandolier;Feb2007, Vol. 14 Issue 2, p4 

    The article presents information on estimated glomerular filtration rate (eGFR). It notes that GFR in healthy young men and women is about 130 and 120 milliliter per minute. It also mentions that eGFR will pick up impaired renal function and most of what it does pick up tends to be in older...

  • Glomerular Filtration Rate.  // Encyclopedic Reference of Molecular Pharmacology;2004, p404 

    A definition of the term "glomerular filtration rate" (GFR) is presented. It refers to the volume of plasma-like fluid that is filtered per unit time across the glomerular capillary membranes to enter the tubular space. Reductions in GFR are often accompanied by parallel reductions in urine...

  • Evaluation of pre-implantation kidney biopsies: Comparison of Banff criteria to a morphometric approach. Lopes, José António; Moreso, Francesc; Riera, Luis; Carrera, Marta; Ibernon, Meritxell; Fulladosa, Xavier; Grinyó, Josep Maria; Serón, Daniel // Kidney International;Apr2005, Vol. 67 Issue 4, p1595 

    Evaluation of pre-implantation kidney biopsies: Comparison of Banff criteria to a morphometric approach.Background.Donor glomerulosclerosis, interstitial fibrosis, and fibrous intimal thickening correlate with graft outcome. We evaluate chronic lesions in donor biopsies according to Banff...

  • A Microtechnique for Radioisotopic Determination of Glomerular Filtration Rate in Infants and Children. Braren, Victor; Brill, A. Bertrand; Touya, Juan; Goddard, John // Clinical Pediatrics;Apr1982, Vol. 21 Issue 4, p225 

    Our experience with a microtechnique using 99mTc-DTPA for determination of glomerular filtration rate in 172 children is presented. It is a simple finger-stick method carried out in a four-hour time period by trained nuclear medical personnel. The procedure meets all criteria for precise...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics