P300 amplitude is insensitive to working memory load in schizophrenia

Gaspar, Pablo A.; Ruiz, Sergio; Zamorano, Francisco; Altayó, Marcela; Pérez, Carolina; Bosman, Conrado A.; Aboitiz, Francisco
January 2011
BMC Psychiatry;2011, Vol. 11 Issue 1, p29
Academic Journal
Background: Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to have an aberrant brain connectivity and impairments in WM capacity. The aim of this study was to determine the dependency of the P300 component on WM load in a sample of SZ subjects. Methods: We recorded 26 subjects (13 SZ patients and their matched controls) with an 80-channel electroencephalogram. Subjects performed an N-back task, a WM paradigm that manipulates the number of items to be stored in memory. Results: In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the attentional control condition and the high WM load condition. In contrast, SZs evidenced low P300 amplitude in all conditions. A significant between group difference in P300 amplitude was evidenced only at the low WM load condition (1 -back), being smaller in SZs. Conclusions: SZ subjects display a lower than normal P300 amplitude, which does not vary as a function of memory load. These results are consistent with a general impairment in WM capacity in these patients.


Related Articles

  • Contribution of Working Memory Components to the Performance of the Tower of Hanoi in Schizophrenia. Chan, R. C. K.; Wang, Y. N.; Cao, X. Y.; Chen, E. Y. H. // East Asian Archives of Psychiatry;Jun2010, Vol. 20 Issue 2, p69 

    Objectives: To examine the underlying structure of neuropsychological tests involving working memory components and those not involving working memory components that contribute to the performance of the Tower of Hanoi task in schizophrenic patients. Participants and Methods: A total of 90...

  • Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas. Kircher, Tilo; Thienel, Renate; Wagner, Michael; Reske, Martina; Habel, Ute; Kellermann, Thilo; Frommann, Ingo; Schwab, Sibylle; W�lwer, Wolfgang; von Wilmsdorf, Martina; Braus, Dieter F.; Schmitt, Andrea; Rapp, Alexander; St�cker, Tony; Shah, N. Jon; Henn, Fritz A.; Sauer, Heinrich; Gaebel, Wolfgang; Maier, Wolfgang; Schneider, Frank // European Archives of Psychiatry & Clinical Neuroscience;Mar2009, Vol. 259 Issue 2, p72 

    The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal...

  • Nicotine improves delayed recognition in schizophrenic patients. Myers, Carol S.; Robles, Olalla; Kakoyannis, A. Nancy; Sherr, Jay D.; Avila, Matthew T.; Blaxton, Teresa A.; Thaker, Gunvant K. // Psychopharmacology;2004, Vol. 174 Issue 3, p334 

    Rationale. Nicotine has been shown to enhance some aspects of memory, attention and cognition in normal subjects and in some patient populations such as Alzheimer’s and Parkinson’s disease groups. Objectives. Memory disorders are consistently observed in schizophrenic patients, so...

  • Polymorphism of Serotonin Receptor Genes (5-HTR2A) and Dysbindin (DTNBP1) and Individual Components of Short-Term Verbal Memory Processes in Schizophrenia. Alfimova, M. V.; Monakhov, M. V.; Abramova, L. I.; Golubev, S. A.; Golimbet, V. E. // Neuroscience & Behavioral Physiology;Oct2010, Vol. 40 Issue 8, p934 

    ociations between polymorphisms in the T102C and A-1438G loci of the 5-HTR2A and the P1763 and P1578 markers of the DTNBP1 gene with the overall productivity and individual subprocesses of shortterm verbal memory were studied in 4–5 patients with schizophrenia and 290 healthy subjects....

  • Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling. Barnett, Jennifer H.; Croudace, Tim J.; Jaycock, Sue; Blackwell, Candice; Hynes, Fiona; Sahakian, Barbara J.; Joyce, Eileen M.; Jones, Peter B. // BMC Psychiatry;2007, Vol. 7, p16 

    Background: Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function. Methods: This longitudinal study aimed to establish whether there was stability, improvement or decline in memory...

  • Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.  // Current Medical Literature: Psychiatry;2004, Vol. 15 Issue 2, p45 

    Discusses research being done on the function of the dorsolateral prefrontal cortex in schizophrenia. Reference to a study by J. H. Callicott, V. S. Mattay, B. A. Verchinski, S. Marenco and M. F. Egan, published in the 2003 issue of the "American Journal of Psychiatry"; Methodology used;...

  • Schizophrenia and Related Disorders.  // Current Medical Literature: Psychiatry;2006, Vol. 17 Issue 4, p122 

    The article reflects on studies about schizophrenia and related disorders. It explains the Theory of Mind deficits in schizophrenia patients. It recommends further research on the working memory process in schizophrenia. It points out the value of a study that analyzed the structure of the...

  • Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis. Turkoz, Ibrahim; Bossie, Cynthia A.; Lindenmayer, Jean-Pierre; Schooler, Nina; Canuso, Carla M. // BMC Psychiatry;2011, Vol. 11 Issue 1, p21 

    Background: To compare the efficacy and tolerability of paliperidone extended-release (ER) with risperidone immediate-release using propensity score methodology. Methods: Six double-blind, randomized, placebo-controlled, short-term clinical trials for acute schizophrenia with availability of...

  • Dose-associated changes in safety and efficacy parameters observed in a 24-week maintenance trial of olanzapine long-acting injection in patients with schizophrenia. Hill, Angela L.; Bin Sun; Karagianis, Jamie L.; Watson, Susan B.; McDonnell, David P. // BMC Psychiatry;2011, Vol. 11 Issue 1, p28 

    Background: In a recently published 24-week maintenance study of olanzapine long-acting injection (LAI) in schizophrenia (Kane et al., 2010), apparent dose-associated changes were noted in both efficacy and safety parameters. To help clinicians balance safety and efficacy when choosing a dose of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics