TITLE

Design and methods of a longitudinal study investigating the impact of antiretroviral treatment on the partnerships and sexual behaviour of HIV-infected individuals in rural KwaZulu-Natal, South Africa

AUTHOR(S)
McGrath, Nuala; Richter, Linda; Newell, Marie-Louise
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011, Vol. 11 Issue 1, p121
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Diagnosed HIV-infected people form an increasingly large sub-population in South Africa, one that will continue to grow with widely promoted HIV testing and greater availability of antiretroviral therapy (ART). For HIV prevention and support, understanding the impact of long-term ART on family and sexual relationships is a health research priority. This includes improving the availability of longitudinal demographic and health data on HIV-infected individuals who have accessed ART services but who are not yet ART-eligible. Design and methods: The aim of the study is to investigate the impact of ART on family and partner relationships, and sexual behaviour of HIV-infected individuals accessing a public HIV treatment and care programme in rural South Africa. HIV-infected men and women aged 18 years or older attending three clinics are screened. Those people initiating ART because they meet the criteria of WHO stage 4 or CD4 ≤ 200 cells/μL are assigned to an 'ART initiator' group. A 'Monitoring' group is composed of people whose most recent CD4 count was >500 cells/μL and are therefore, not yet eligible for ART. During the four-year study, data on both groups is collected every 6 months during clinic visits, or where necessary by home visits or phone. Detailed information is collected on social, demographic and health characteristics including living arrangements, past and current partnerships, sexual behaviour, HIV testing and disclosure, stigma, self-efficacy, quality of family and partner relationships, fertility and fertility intentions, ART knowledge and attitudes, and gender norms. Recruitment for both groups started in January 2009. As of October 2010, 600 participants have been enrolled; 386 in the ART initiator group (141, 37% male) and 214 in the Monitoring group (31, 14% male). Recruitment remains open for the Monitoring group. Discussion: The data collected in this study will provide valuable information for measuring the impact of ART on sexual behaviour, and for the planning and delivery of appropriate interventions to promote family and partner support, and safe sexual behaviour for people living with HIV in this setting and elsewhere in sub-Saharan Africa.
ACCESSION #
59754526

 

Related Articles

  • HAART and Sexual Risk Behavior—Reply. Crepaz, Nicole; Marks, Gary; Hart, Trevor A. // JAMA: Journal of the American Medical Association;11/17/2004, Vol. 292 Issue 19, p2335 

    Presents a letter to the editor in reply to readers' responses to the authors' study of HIV-positive patients, their sexual behavior, and HAART.

  • HAART and Sexual Risk Behavior. Diamond, Catherine // JAMA: Journal of the American Medical Association;11/17/2004, Vol. 292 Issue 19, p2335 

    Presents a letter to the editor concerning research by Dr. Crepaz and colleagues on sexual behavior in HIV-infected patients taking highly active antiretroviral therapy (HAART).

  • Comparative Evaluation of Adherence to Antiretroviral Therapy in Sub-Saharan African Native HIV-Infected Patients in France and Africa. Sellier, Pierre; Clevenbergh, Philippe; Ljubicic, Liliana; Simoneau, Guy; Evans, John; Delcey, Véronique; Diemer, Myriam; Bendenoun, Marc; Mouly, Stéphane; Bergmann, Jean-François // Clinical Infectious Diseases;9/1/2006, Vol. 43 Issue 5, p654 

    Patients with human immunodeficiency virus (HIV) infection who were native to sub-Saharan Africa but lived in France were less adherent to antiretroviral therapy during a visit back to Africa, compared with their level of adherence in France. This was mainly related to self-perceived...

  • Mucosal immunity in human and simian immunodeficiency lentivirus infections. Brenchley, J M // Mucosal Immunology (1933-0219);Jul2013, Vol. 6 Issue 4, p657 

    Overwhelming evidence indicates that distinct pathological phenomenon occurs within the gastrointestinal (GI) tract of progressively simian immunodeficiency virus (SIV)-infected Asian macaques and HIV-infected humans compared with other anatomical sites. Massive loss of GI tract lamina propria...

  • As GPs' HIV role widens -- what you need to know. Williams, Olwen // Pulse;7/2/2005, Vol. 65 Issue 26, p48 

    Reports on the widening role of general practitioners (GPs) in Great Britain in HIV infection treatment. Reasons behind the increasing pressure on GPs to help HIV-positive patients; Features of HIV testing in primary care; Rules governing health insurance acquisition for HIV-positive people;...

  • Factors Influencing Increases in CD4 Cell Counts of HIV-Positive Persons Receiving Long-Term Highly Active Antiretroviral Therapy. Smith, Colette J.; Sabin, Caroline A.; Youle, Mike S.; Loes, Sabine Kinloch-de; Lampe, Fiona C.; Madge, Sara; Cropley, Ian; Johnson, Margaret A.; Phillips, Andrew N. // Journal of Infectious Diseases;11/15/2004, Vol. 190 Issue 10, p1860 

    Background. Highly active antiretroviral therapy (HAART) results in an improvement in immunologic function. We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART. Methods....

  • Changes in sexual desires and behaviours of people living with HIV after initiation of ART: Implications for HIV prevention and health promotion.  // BMC Public Health;2011, Vol. 11 Issue 1, p633 

    The article focuses on the study conducted to examine the changes in sexual desires and behaviors of people with HIV disease after initiating antiretroviral treatment (ART) in Uganda. It mentions that sexual desire changed with many reporting diminished desire on ART. It also mentions that...

  • Eliminating Persistent HIV Infection: Getting to the End of the Rainbow. Margolis, David M.; Archin, Nancie M. // Journal of Infectious Diseases;6/15/2007, Vol. 195 Issue 12, p1734 

    This article comments on challenges that the medical fraternity faces to eradicate established HIV infection. The article makes specific reference to the study "Decay of the HIV Reservoir in Patients Receiving of Antiretroviral Therapy for Extended Periods: Implications for Eradication of...

  • Psychiatric and Social Barriers to HIV Medication Adherence in a Triply Diagnosed Methadone Population. Palmer, Nancy B.; Salcedo, Jesus; Miller, Alec L.; Winiarski, Mark; Arno, Peter // AIDS Patient Care & STDs;Dec2003, Vol. 17 Issue 12, p635 

    Although antiretrovirals can prolong life, medication adherence also poses a constant challenge for HIV-infected individuals because the success of antiretroviral regimens demands nearly perfect adherence to medications. This paper describes the psychiatric and social barriers to adherence in a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics