Fospropofol Is Tolerable and Effective in Mechanically Ventilated ICU Patients

Baney, Jack
March 2011
Pulmonary Reviews;Mar2011, Vol. 16 Issue 3, p17
The article reports on the safe and effective use of fospropofol, a prodrug of profopol, to sedate patients under mechanical ventilation in an intensive care unit (ICU), both on its administration by bolus and infusion or by infusion alone. It is shown that the water soluble fospropofol is linked with a gradual rise toward therapeutic propofol concentration followed by a gradual decline after bolus dosing. These properties reportedly lead to longer therapeutic exposure to the active drug.


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