TITLE

Metallacarboranes for the labelling of DNA - Synthesis of oligonucleotides bearing a 3,3′-iron-1,2,1′,2′-dicarbollide complex

AUTHOR(S)
Olejniczak, Agnieszka B.
PUB. DATE
April 2011
SOURCE
Canadian Journal of Chemistry;Apr2011, Vol. 89 Issue 4, p465
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present work reports the efficient synthesis of oligonucleotides bearing metallacarborane complexes containing iron (3,3′-iron-1,2,1′,2′-dicarbollide) on a solid support via the H-phosphonate method. This versatile methodology can be applied to the synthesis of DNA oligomers bearing various metallacarborane units. Dans ce travail, on rapporte la synthèse efficace d'oligonucléotides portant des métallacarboranes contenant du fer (3,3′-fer-1,2,1′2′-dicarbollide) sur un support solide en faisant appel à la méthode du H-phosphonate. Cette méthodologie versatile peut être appliquée à la synthèse d'oligomères de l'ADN portant diverses unités métallacarboranes.
ACCESSION #
59631189

 

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